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Trifluoroacetylation of pyrrolo[1,2-a]pyrazines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A study was carried out on the reaction of pyrrolo[1,2-a]pyrazines containing an alkyl, aryl, or aralkyl substituent at C-1 with trifluoroacetic anhydride. Trifluoroacetylation products may be formed either by reaction in the pyrrole ring or at the aryl or aralkyl groups at C-1. Products of electrophilic substitution at C-6 are formed in the trifluoroacetylation of pyrrolo[1,2-a]pyrazines containing at C-1 a substituent bulkier than a methyl group but lacking substituents at C-6 (the α-position of the pyrrole ring).

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Authors and Affiliations

  1. Chemistry Faculty, M. V. Lomonosov Moscow State University, Moscow, 119899, Russia

    V. I. Terenin, E. V. Kabanova, N. A. Tselishcheva, A. S. Ivanov & N. V. Zyk

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  1. V. I. Terenin
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  2. E. V. Kabanova
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  3. N. A. Tselishcheva
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  4. A. S. Ivanov
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  5. N. V. Zyk
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1226–1233, August, 2007.

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Terenin, V.I., Kabanova, E.V., Tselishcheva, N.A. et al. Trifluoroacetylation of pyrrolo[1,2-a]pyrazines. Chem Heterocycl Comp 43, 1038–1043 (2007). https://doi.org/10.1007/s10593-007-0162-2

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  • DOI: https://doi.org/10.1007/s10593-007-0162-2

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