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Heterocyclic analogs of 5,12-naphthacenequinone. 4. Synthesis of 4,11-dimethoxy-anthra[2,3-d]isoxazole-5,10-dione

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A preparative synthetic method has been developed for 3-chloro-2-formyl-1,4-dimethoxyanthraquinone starting from available 2-methylquinizarine. The condensation of the α-chloroaldehyde obtained with acetone oxime gives 4,11-dimethoxyanthra[2,3-d]isoxazole-5,10-dione.

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Authors and Affiliations

  1. G. F. Gauze Institute of New Antibiotics, Russian Academy of Medical Science, 119021, Moscow, Russia

    A. E. Shchekotikhin, Yu. N. Luzikov & M. N. Preobrazhenskaya

  2. D. I. Mendeleev University of Chemical Technology of Russian, 125190, Moscow, Russia

    V. N. Buyanov

Authors
  1. A. E. Shchekotikhin
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  2. Yu. N. Luzikov
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  3. V. N. Buyanov
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  4. M. N. Preobrazhenskaya
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1421–1427, September, 2006.

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Shchekotikhin, A.E., Luzikov, Y.N., Buyanov, V.N. et al. Heterocyclic analogs of 5,12-naphthacenequinone. 4. Synthesis of 4,11-dimethoxy-anthra[2,3-d]isoxazole-5,10-dione. Chem Heterocycl Compd 42, 1236–1241 (2006). https://doi.org/10.1007/s10593-006-0232-x

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  • DOI: https://doi.org/10.1007/s10593-006-0232-x

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