Skip to main content
SpringerLink
Log in

4-Hydroxyquinolones-2. 91. Synthesis and properties of ethyl 1-R-4-hydroxy-6-methyl-2-oxo-dihydropyridine-5-carboxylates

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of ethyl aminocrotonates with derivatives of malonic acid is a suitable method for the preparation of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-5-carboxylates. One of the synthesized materials has been studied by X-ray crystallography.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. V. Ukrainets, L. V. Sidorenko, L. A. Petrushova, and O. V. Gorokhova, Khim. Geterotsikl. Soedin., 70 (2006).

  2. P. Kaheinen, P. Pollsello, J. Levijoki, and H. Haikala, J. Cardiovasc. Pharmacol., 43, 555 (2004).

    Article  CAS  Google Scholar 

  3. L. Nagata, M. Iwase, T. Sobue, and M. Yokota, J. Am. Coll. Cardiol., 25, 295 (1995).

    Article  CAS  Google Scholar 

  4. L. Rivers, A. J. Groom, S. Hatakeyama, K. Kawano, H. Naka, K. Ueno, M. Ueno, H. Amino, T. Hanada, K. Ito, M. Nagato, M. Ogo, Y. Urawa, and Y. Norimine, US Pat. 2004023973 (2004); http://ep.espacenet.com

  5. S. Suda, M. Yamanaka, T. Ogawa, K. Miyake, and H. Ohara, Chem. Pharm. Bull., 39, 1556 (1991).

    Google Scholar 

  6. R. C. Isaacs, K. J. Kutrona, C. L. Newton, P. E. Sanderson, M. G. Solinsky, E. P. Baskin, I. W. Chen, C. M. Cooper, J. J. Cook, S. J. Gardell, S. D. Lewis, R. J. Lucas, E. A. Lyle, J. J. Lynch, A. M. Naylor-Olsen, M. J. Stranieri, K. Vastag, and J. P. Vacca, Bioorg. Med. Chem. Lett., 8, 1719 (1998).

    Article  CAS  Google Scholar 

  7. M. A. Ghannoum, V. Chaturvedi, A. Espinel-Ingroff, M. A. Pfaller, M. G. Rinaldi, W. Lee-Yang, and D. W. Warnock, J. Clin. Microbiol., 42, 2977 (2004).

    Article  CAS  Google Scholar 

  8. W. S. Saari, J. S. Wai, T. E. Fischer, C. M. Thomas, J. M. Hoffman, C. S. Rooney, A. M. Smith, J. H. Jones, D. L. Bamberger, and M. E. Goldman, J. Med. Chem., 35, 3792 (1992).

    Article  CAS  Google Scholar 

  9. A. Kleeman and J. Engel, Pharmaceutical Substances. Synthesis, Patents, Applications, Multimedia Viewer, Version 2.00. Georg Thieme Verlag, Stuttgart, 2001.

    Google Scholar 

  10. I. V. Ukrainets, O. V. Gorokhova, S. G. Taran, P. A. Bezuglii, A. V. Turov, N. A. Marusenko, and O. A. Evtifeeva, Khim. Geterotsikl. Soedin., 958 (1994).

  11. Yu. V. Zefirov and I. M. Zorkii, Uspekhi Khimii, 64, 446 (1995).

    CAS  Google Scholar 

  12. H.-B. Burgi and J. D. Dunitz, Struc. Correl., VCH, Weinheim, 1994, 2, 741.

    Google Scholar 

  13. I. V. Ukrainets, K. A. Taran, L. V. Sidorenko, I. Yu. Petukhova, and N. I. Filimonova, Visnik Farmatsii, No. 2 (26), 3 (2001).

  14. Weygand-Gilgetag Experimental Methods in Organic Chemistry [Russian translation], Khimiya, Moscow, 1969, 473.

    Google Scholar 

  15. G. M. Sheldrick, SHELXTL PLUS. PC Version. A System of Computer Programs for the Determination of Crystal Structures from X-ray Diffraction Data. Rev. 5.02 (1994).

Download references

Author information

Authors and Affiliations

  1. National Pharmaceutical University, Kharkov, 61002, Ukraine

    I. V. Ukrainets, L. V. Sidorenko & O. V. Gorokhova

  2. Institute of Scintillation Materials, Ukraine National Academy of Sciences, Kharkov, 6101, Ukraine

    O. V. Shishkin

Authors
  1. I. V. Ukrainets
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Sidorenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. V. Gorokhova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. V. Shishkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, 217–223, February, 2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ukrainets, I.V., Sidorenko, L.V., Gorokhova, O.V. et al. 4-Hydroxyquinolones-2. 91. Synthesis and properties of ethyl 1-R-4-hydroxy-6-methyl-2-oxo-dihydropyridine-5-carboxylates. Chem Heterocycl Compd 42, 191–196 (2006). https://doi.org/10.1007/s10593-006-0070-x

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-006-0070-x

Keywords

Search

Navigation