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New Procedure for Obtaining Indomethacin

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A new procedure has been developed for the synthesis of indomethacin by the Fischer reaction, based on the acylation of sodium 2-(4-methoxyphenyl)-1-hydrazosulfonate with 4-chlorobenzoyl chloride and subsequent interaction with levulinic acid in the presence of formic acid.

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REFERENCES

  1. M. D. Mashkovskii, Drugs [in Russian], Vilnius (1994).

  2. L. H. Sarret, T. Y. Shen, and T. B. Winderholz, J. Am. Chem. Soc., 85, 488 (1963).

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  3. M. Sletzinger, G. Gal, and J. M. Chemerda, Fr. Patent 1540724; Chem. Abstr., 71, P81159 (1969).

    Google Scholar 

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Authors and Affiliations

  1. Moscow K. A. Timiryazev Agricultural Academy, Moscow, 127550, Russia

    I. V. Magedov

  2. Novomoscovsk Institute of the Russian D. I. Mendeleev University of Chemical Technology, Novomoscovsk, 301670, Russia

    S. A. Maklakov

  3. Russian D. I. Mendeleev University of Chemical Technology, Moscow, 125047, Russia

    Yu. I. Smushkevich

Authors
  1. I. V. Magedov
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  2. S. A. Maklakov
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  3. Yu. I. Smushkevich
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 530–532, April, 2005.

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Magedov, I.V., Maklakov, S.A. & Smushkevich, Y.I. New Procedure for Obtaining Indomethacin. Chem Heterocycl Compd 41, 449–451 (2005). https://doi.org/10.1007/s10593-005-0169-5

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  • DOI: https://doi.org/10.1007/s10593-005-0169-5

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