Skip to main content
Log in

Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma

  • Letters to the Editor
  • Published:
Clinical & Experimental Metastasis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Data availability

Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.

References

  1. Leong SP (2021) Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®). Clin Exp Metastasis. https://doi.org/10.1007/s10585-021-10137-4. Online ahead of print

  2. Garrel R, Poissonnet G, Moyà Plana A, Fakhry N, Dolivet G, Lallemant B, Sarini J, Vergez S, Guelfucci B, Choussy O, Bastit V, Richard F, Costes V, Landais P, Perriard F, Daures JP, de Verbizier D, Favier V, de Boutray M (2020) Equivalence randomized trial to compare treatment on the basis of sentinel node biopsy versus neck node dissection in operable T1–T2N0 oral and oropharyngeal cancer. J Clin Oncol 38(34):4010–4018. https://doi.org/10.1200/JCO.20.01661

    Article  PubMed  Google Scholar 

  3. Hasegawa Y, Tsukahara K, Yoshimoto S, Miura K, Yokoyama J, Hirano S, Uemura H, Sugasawa M, Yoshizaki T, Homma A, Chikamatsu K, Suzuki M, Shiotani A, Matsuzuka T, Kohno N, Miyazaki M, Oze I, Matsuo K, Kosuda S, Yatabe Y, HNCMM Research Group (2021) Neck dissections based on sentinel lymph node navigation versus elective neck dissections in early oral cancers: a randomized, multicenter, and noninferiority trial. J Clin Oncol 39(18):2025–2036. https://doi.org/10.1200/JCO.20.03637

    Article  CAS  PubMed  Google Scholar 

  4. Lai SY, Ferris RL (2020) Evolving evidence in support of sentinel lymph node biopsy for early-stage oral cavity cancer. J Clin Oncol 38(34):3983–3986. https://doi.org/10.1200/JCO.20.02716

    Article  PubMed  Google Scholar 

  5. Civantos FJ, Zitsch RP, Schuller DE, Agrawal A, Smith RB, Nason R, Petruzelli G, Gourin CG, Wong RJ, Ferris RL, El Naggar A, Ridge JA, Paniello RC, Owzar K, McCall L, Chepeha DB, Yarbrough WG, Myers JN (2010) Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1–T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol 28(8):1395–1400. https://doi.org/10.1200/JCO.2008.20.8777

    Article  PubMed  PubMed Central  Google Scholar 

  6. Schilling C, Stoeckli SJ, Haerle SK, Broglie MA, Huber GF, Sorensen JA, Bakholdt V, Krogdahl A, von Buchwald C, Bilde A, Sebbesen LR, Odell E, Gurney B, O’Doherty M, de Bree R, Bloemena E, Flach GB, Villarreal PM, Fresno Forcelledo MF, Junquera Gutiérrez LM, Amézaga JA, Barbier L, Santamaría-Zuazua J, Moreira A, Jacome M, Vigili MG, Rahimi S, Tartaglione G, Lawson G, Nollevaux MC, Grandi C, Donner D, Bragantini E, Dequanter D, Lothaire P, Poli T, Silini EM, Sesenna E, Dolivet G, Mastronicola R, Leroux A, Sassoon I, Sloan P, McGurk M (2015) Sentinel european node trial (SENT): 3-year results of sentinel node biopsy in oral cancer. Eur J Cancer 51(18):2777–2784

    Article  Google Scholar 

  7. Agrawal A, Civantos FJ, Brumund KT, Chepeha DB, Hall NC, Carroll WR, Smith RB, Zitsch RP, Lee WT, Shnayder Y, Cognetti DM, Pitman KT, King DW, Christman LA, Lai SY (2015) [(99m)Tc]Tilmanocept accurately detects sentinel lymph nodes and predicts node pathology status in patients with oral squamous cell carcinoma of the head and neck: results of a phase iii multi-institutional trial. Ann Surg Oncol 22(11):3708–3715. https://doi.org/10.1245/s10434-015-4382-x

    Article  PubMed  PubMed Central  Google Scholar 

  8. Gupta T, Maheshwari G, Kannan S, Nair S, Chaturvedi P, Agarwal JP (2022) Systematic review and meta-analysis of randomized controlled trials comparing elective neck dissection versus sentinel lymph node biopsy in early-stage clinically node-negative oral and/or oropharyngeal squamous cell carcinoma: evidence-base for practice and implications for research. Oral Oncol 124:105642. https://doi.org/10.1016/j.oraloncology.2021.105642

    Article  CAS  PubMed  Google Scholar 

  9. den Toom IJ, Boeve K, Lobeek D, Bloemena E, Donswijk ML, de Keizer B, Klop WMC, Leemans CR, Willems SM, Takes RP, Witjes MJH, de Bree R (2020) Elective neck dissection or sentinel lymph node biopsy in early stage oral cavity cancer patients: the dutch experience. Cancers 12(7):1783. https://doi.org/10.3389/fonc.2021.644306

    Article  Google Scholar 

  10. den Toom IJ, Mahieu R, van Rooij R, van Es RJJ, Hobbelink MGG, Krijger GC, Tijink BM, de Keizer B, de Bree R (2021) Sentinel lymph node detection in oral cancer: a within-patient comparison between [99m Tc]Tc-tilmanocept and [99m Tc]Tc-nanocolloid. Eur J Nucl Med Mol Imaging 48(3):851–858. https://doi.org/10.1007/s00259-020-04984-8

    Article  CAS  Google Scholar 

  11. Mahieu R, den Toom IJ, van Rooij R, van Es RJJ, Hobbelink MGG, Krijger GC, Tijink BM, de Keizer B, de Bree R (2021) Diagnostic accuracy of [99m Tc]Tc-tilmanocept compared to [99m Tc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer. Clin Otolaryngol 46(6):1383–1388. https://doi.org/10.1111/coa.13798

    Article  PubMed  Google Scholar 

  12. Mahieu R, Donders DNV, Krijger GC, Ververs FFT, de Roos R, Bemelmans JLMM, van Rooij R, de Bree R, de Keizer B (2021) Within-patient comparison between [ 68 Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [ 99m Tc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study. Eur J Nucl Med Mol Imaging. https://doi.org/10.1007/s00259-021-05645-0. Online ahead of print.

Download references

Funding

The first author received a grant for research on Lymphoseek and sentinel node biopsy in oral cancer from SpePharm A.G.—part of the Norgine Group of companies, Amsterdam, The Netherlands.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Remco de Bree.

Ethics declarations

Conflict of interest

No other conflict of interest amongst authors and all authors have contributed towards the article. There are no financial affiliations, and the authors have nothing else to disclose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Bree, R., Mahieu, R., Donders, D.N.V. et al. Detection of sentinel lymph nodes by tilmanocept in oral squamous cell carcinoma. Clin Exp Metastasis 39, 417–419 (2022). https://doi.org/10.1007/s10585-022-10159-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10585-022-10159-6

Navigation