Abstract
This summit focusing on lymphedema following cancer therapy was held during the 7th International Symposium on Cancer Metastasis through the Lymphovascular System. It was unique for the inclusion of patients with lymphedema joining physicians, therapists, healthcare professionals, and researchers to highlight what is known and more importantly what is unknown about the current state of research and treatment in the United States. The session opened with an introduction to lymphedema and then explored the incidence of multiple cancer-related lymphedemas, imaging tools and techniques useful for the diagnosis of lymphatic system abnormalities, and the new findings concerning the genetics of cancer-related lymphedema. It closed with a review of advocacy for patients and healthcare professionals and both conservative and surgical treatment options, followed by a panel discussion and questions. The session provided important information and updates which will be of value for improving the rehabilitation and overall support of patients with cancer-related lymphedema.
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References
International Society of Lymphology (2016) The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the international society of lymphology. Lymphology 49:170–184
Armer JM, Stewart BR, Shook RP (2009) 30-month post-breast cancer treatment lymphoedema. J Lymphoedema 4(1):14–18
Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM (2010) Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer 116(22):5138–5149
Asellius G. De lactibus venis quarto vasorum mesaraicorum genere novo inuento, Mediolani, 1627, JB Biddellium. Reproduced in 1972 by Epistem Editrice, Milano
Natale G, Bocci G, Ribatti D (2017) Scholars and scientists in the history of the lymphatic system. J Anat 231(3):417–429
Kinmonth JB (1972) The lymphatics: diseases, lymphography and surgery. Williams & Wilkins, Baltimore
Bernas M (2013) Imaging of the lymphatic system. In: Lymphedema management: the comprehensive guide for practitioners, 3rd edn. Thieme, New York
Witte CL, Witte MH, Unger EC, Williams WH, Bernas MJ, McNeill GC, Stazzone AM (2000) Advances in imaging of lymph flow disorders. Radiographics 20(6):1697–1719
Yamamoto T, Matsuda N, Doi K, Oshima A, Yoshimatsu H, Todokoro T, Ogata F, Mihara M, Narushima M, Iida T, Koshima I (2011) The earliest finding of indocyanine green lymphography in asymptomatic limbs of lower extremity lymphedema patients secondary to cancer treatment: the modified dermal backflow stage and concept of subclinical lymphedema. Plast Reconstr Surg 128(4):314e–321e
Dori Y, Keller MS, Fogel MA, Rome JJ, Whitehead KK, Harris MA, Itkin M (2014) MRI of lymphatic abnormalities after functional single-ventricle palliation surgery. AJR 203:426–431
Rane S, Donahue PMC, Towse T, Ridner S, Chappell M, Jordi J, Gore J, Donahue MJ (2013) Clinical feasibility of noninvasive visualization of lymphatic flow with principles of spin labeling MR imaging: implications for lymphedema assessment. Radiology 269:893–902
Brouillard P, Boon L, Vikkula M (2014) Genetics of lymphatic anomalies. J Clin Invest 124(3):898–904
Connell FC, Gordon K, Brice G, Keeley V, Jeffery S, Mortimer PS, Mansour S, Ostergaard P (2013) The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings. Clin Genet 84:303–314
Finegold DN, Schacht V, Kimak MA, Lawrence EC, Foeldi E, Karlsson JM, Baty CJ, Ferrell RE (2008) HGF and MET mutations in primary and secondary lymphedema. Lymphat Res Biol 6:65–68
Finegold DN, Baty CJ, Knickelbein KZ, Perschke S, Noon SE, Campbell D, Karlsson JM, Huang D, Kimak MA, Lawrence EC, Feingold E, Meriney SD, Brufsky AM, Ferrell RE (2012) Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment. Clin Cancer Res 18(8):1–9
Newman B, Lose F, Kedda M-A, Francois M, Ferguson K, Janda M, Yates P, Spurdle AB, Hayes SC (2012) Possible genetic predisposition to lymphedema after breast cancer. Lymphat Res Biol 10:2–13
Fu MR, Conley YP, Axelrod D, Guth AA, Yu G, Fletcher J, Zagzag D (2016) Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction. Breast 29:231–240
Miaskowski C, Dodd M, Paul SM, West C, Hamolsky D, Abrams G, Cooper BA, Elboim C, Neuhaus J, Schmidt BL, Smoot B, Aouizeratet BE (2013) Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. PLoS ONE 8(4):e60164
Leung G, Baggott C, West C, Elboim C, Paul SM, Cooper BA, Abrams G, Dhruva A, Schmidt BL, Kober K, Merriman JD, Leutwyler H, Neuhaus J, Langford D, Smoot BJ, Aouizerat BE, Miaskowski C (2014) Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery. Lymphat Res Biol 12(1):10–22
Smoot B, Kober KM, Paul SM, Levine JD, Abrams G, Mastick J, Topp K, Conley YP, Miaskowski CA (2017) Potassium channel candidate genes predict the development of secondary lymphedema following breast cancer surgery. Nurs Res 66(2):85–94
Tam K, Shen L, Munneke JR, Ackerson LM, Partee PN, Somkin CP, Andre M, Kutner SE, Thiadens SRJ, Kwan ML (2012) Clinician awareness and knowledge of BCRL in a large, integrated healthcare delivery setting. Breast Cancer Res Treat 131(3):1029–1038
Lasinski BB, McKillip Thrift K, Squire D, Austin MK, Smith KM, Wanchai A, Green JM, Stewart BR, Cormier JN, Armer JM (2012) A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011. PM&R 4(8):580–601
Armer JM, Hulett JM, Bernas M, Ostby P, Stewart BR, Cormier JN (2013) Best practice guidelines in assessment, risk reduction, management, and surveillance for post-breast cancer lymphedema. Curr Breast Cancer Rep 5(2):134–144
Fu MR, Deng J, Armer JM (2014) Putting evidence into practice: cancer-related lymphedema. Clin J Oncol Nurs 18(Suppl):68–79
Boccardo F, Casabona F, De Cian F, Friedman D, Villa G, Bogliolo S, Ferrero S, Murelli F, Campisi C (2009) Lymphedema microsurgical preventive healing approach: a new technique for primary prevention of arm lymphedema after mastectomy. Ann Surg Oncol 16:703–708
Box RC, Reul-Hirche HM, Bullock-Saxton JE, Furnival CM (2002) Physiotherapy after breast cancer surgery: results of a randomized controlled study to minimise lymphedema. Breast Cancer Res Treat 75:51–64
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Bernas, M., Thiadens, S.R.J., Smoot, B. et al. Lymphedema following cancer therapy: overview and options. Clin Exp Metastasis 35, 547–551 (2018). https://doi.org/10.1007/s10585-018-9899-5
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DOI: https://doi.org/10.1007/s10585-018-9899-5