Skip to main content

Advertisement

Log in

Improved rodent models of human brain metastases

  • Technical Note
  • Published:
Clinical & Experimental Metastasis Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Daphu I, Sundstrøm T, Horn S, Huszthy PC, Niclou SP, Sakariassen PØ, Immervoll H, Miletic H, Bjerkvig R, Thorsen F (2013) In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis. doi:10.1007/s10585-013-9566-9

    PubMed  Google Scholar 

  2. Kosaka N, Tsuchida T, Uematsu H, Kimura H, Okazawa H, Itoh H (2008) 18F-FDG PET of common enhancing malignant brain tumors. AJR 190(6):W365–W369

    Article  PubMed  Google Scholar 

  3. Wang Y, Chiu E, Rosenberg J, Gambhir SS (2007) Standardized uptake value atlas: characterization of physiological 2-deoxy-2-[18F] fluoro-d-glucose uptake in normal tissues. Mol Imaging Biol 9:83–90

    Article  PubMed  Google Scholar 

  4. Mathews EH, Liebenberg L, Pelzer R (2011) High-glycolytic cancers and their interplay with the body’s glucose demand and supply cycle. Med Hypotheses 76:157–165

    Article  PubMed  CAS  Google Scholar 

  5. Mathews EH, Liebenberg L (2013) Is knowledge of brain metabolism the key to treating highly glycolytic cancers and metastases? Neuro-Oncology. doi:10.1093/neuonc/not041

    PubMed  Google Scholar 

  6. Fidler IJ (2011) The role of organ microenvironment on brain metastasis. Semin Cancer Biol 21(2):107–112

    Article  PubMed  Google Scholar 

  7. Lampson LA (2001) New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns. J Neurooncol 53(3):275–287

    Article  PubMed  CAS  Google Scholar 

  8. Weller M, Cloughesy T, Perry JR, Wick W (2013) Standards of care for treatment of recurrent glioblastoma—are we there yet? Neuro Oncol 15:4–27

    Article  PubMed  Google Scholar 

  9. Wong K-P, Sha W, Zhang X, Huang S-C (2011) Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice. J Nucl Med 52(5):800–807

    Article  PubMed  Google Scholar 

  10. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H (2010) Establishment of in vivo brain imaging method in conscious mice. J Nucl Med 51(7):1068–1075

    Article  PubMed  Google Scholar 

  11. Seyfried TN, Shelton LM, Huysentruyt LC (2013) The VM mouse model of glioblastoma multiforme. Neuromethods 77:39–55

    Article  Google Scholar 

  12. Vince GH, Bendszuz M, Schweitzer T, Goldbrunner RH, Hildebrandt S, Tilgner J, Klein R, Solymosi L, Tonn JC, Roosen K (2004) Spontaneous regression of experimental gliomas—an immunohistochemical and MRI study of the C6 glioma spheroid implantation model. Exp Neurol 190(2):478–485

    Article  PubMed  Google Scholar 

  13. Mathews EH, Liebenberg L (2011) Revival of ‘unsuccessful’ chemotherapeutics for highly glycolytic cancers? Med Hypotheses 77(6):1150

    Article  PubMed  Google Scholar 

  14. Mathews EH, Liebenberg L (2013) Cancer control via glucose and glutamine deprivation. J Intern Med. doi:10.1111/joim.12068

    PubMed  Google Scholar 

  15. Mathews EH, Liebenberg L (2012) Complexity of metabolic cancer control: can we exploit the superior metabolic position of glucose? Cancer Biol Ther 13(8):585

    Article  PubMed  Google Scholar 

  16. Umminger BL (1975) Body size and whole blood sugar concentrations in mammals. Comp Biochem Physiol 52(3):455–458

    Article  CAS  Google Scholar 

  17. Hanauske AR (2009) In Vitro and In Vivo Predictive Tests. In: Hong WK, Bast RC, Hait WN, Kufe DW (eds) Holland-Frei Cancer Medicine, 8th edn. BC Decker, Hamilton

    Google Scholar 

  18. Miura FK, Alves MJF, Rocha MC, da Silva R, Oba-Shinjo SM, Marie SKN (2010) Xenograft transplantation of human malignant astrocytoma cells into immunodeficient rats: an experimental model of glioblastoma. Clinics 65(3):305–309

    PubMed  Google Scholar 

  19. Kamb A (2005) What’s wrong with our cancer models? Nat Rev Drug Discov 4(2):161–165

    Article  PubMed  CAS  Google Scholar 

  20. HogenEsch H, Nikitin AY (2012) Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal models. J Control Release 164(2):183–186

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by TEMM International (Pty) Ltd.

Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leon Liebenberg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mathews, E.H., Liebenberg, L. Improved rodent models of human brain metastases. Clin Exp Metastasis 30, 949–950 (2013). https://doi.org/10.1007/s10585-013-9588-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10585-013-9588-3

Keywords

Navigation