Clinical & Experimental Metastasis

, Volume 26, Issue 1, pp 5–18

Epigenetic contributions to cancer metastasis

Review

Abstract

The molecular basis of cancer encompasses both genetic and epigenetic alterations. These epigenetic changes primarily involve global DNA methylation changes in the form of widespread loss of methylation along with concurrent hypermethylation events in gene regulatory regions that can repress tissue-specific gene expression. Increasingly, the importance of these epigenetic changes to the metastatic process is being realized. Cells may acquire an epi-genotype that permits their dissemination from the primary tumour mass or the ability to survive and proliferate at a secondary tissue site. These epigenetic changes may be cancer-type specific, or in some cases may involve a common target gene providing a selective advantage to multiple metastatic cell types. In this review, I examine the growing volume of literature related to the epigenetic contributions to cancer metastasis. I discuss the functional importance of these epigenetic phenomena and how new epigenetic biomarkers may permit the identification of diagnostic signatures of metastasis and the development of new cancer therapies.

Keywords

Epigenetic Metastasis Hypermethylation Hypomethylation 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Departments of Biochemistry, Oncology and PaediatricsUniversity of Western OntarioLondonCanada
  2. 2.The London Regional Cancer Program, London Health Sciences Centre and the EpiGenWestern Research Group at the Children’s Health Research InstituteLondonCanada
  3. 3.LondonCanada

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