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Cathepsin D-related Disease-free Interval in pT1 Primary Breast Carcinomas: A Pilot Study

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Abstract

In order to address the heterogeneity of the pT1 breast cancer stages, we have been examining the natural and the clinical course of disease in relation to cathepsin D expression, as a molecular marker for the tumor progression that leads to metastasis. The original aim of our pilot study was to determine whether it was possible to distinguish high-risk from low-risk patients, on the basis of nonestrogen- vs. estrogen-regulated cathepsin D expression. Our results showed that estrogen-regulated cathepsin D expression could be useful as surrogate marker of node-positive status. Further, during the natural course of disease, none of 7 pT1N0 patients with tumors bearing nonestrogen-regulated cathepsin D expression developed metastasis. During the clinical course of disease, nonestrogen-regulated cathepsin D expression defined low-risk while estrogen-regulated cathepsin D expression defined high-risk pT1N+ subgroup of patients. Although there is no consensus with respect to metastasis-related prognostic value of cathepsin D expression, our pilot study implies its prognostic value in pT1 breast cancer patients and supports the hypothesis that cathepsin D may promote metastasis in this early stage of disease.

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Authors and Affiliations

  1. Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11 000, Belgrade, Serbia and Montenegro

    D. Nikolić-Vukosavljević, M. Markićević, A. Petrović, K. Kanjer & Z. Nešković-Konstantinović

  2. Institute of Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia and Montenegro

    G. Grujić-Adanja

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  1. D. Nikolić-Vukosavljević
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  2. M. Markićević
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  3. G. Grujić-Adanja
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  4. A. Petrović
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  5. K. Kanjer
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  6. Z. Nešković-Konstantinović
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Correspondence to D. Nikolić-Vukosavljević.

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Nikolić-Vukosavljević, D., Markićević, M., Grujić-Adanja, G. et al. Cathepsin D-related Disease-free Interval in pT1 Primary Breast Carcinomas: A Pilot Study. Clin Exp Metastasis 22, 363–368 (2005). https://doi.org/10.1007/s10585-005-1265-8

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  • DOI: https://doi.org/10.1007/s10585-005-1265-8

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