Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

Abstract

The results of investigation of the regularity of ¹⁸⁸Re binding with KNaHEDP and hydrolysis of the complex compound (¹⁸⁸Re-KNaHEDP) have shown that its quality depends to a considerable extent on the reaction conditions. Concentrations of a reducing agent (Sn²⁺) and stable rhenium in the ¹⁸⁸Re eluate, as the carrier, influence essentially the rate of formation and stability of ¹⁸⁸Re complex with KNaHEDP. The results of the kinetic investigations of the ¹⁸⁸Re-KNaHEDP complex formation prove that the reaction character bears a direct relationship to the concentrations of the complexing agent (Re) and the reducer (Sn²⁺).

The higher ratio of Re⁷⁺: Sn²⁺ concentrations, the more effectively ¹⁸⁸Re binds with KNaHEDP. The obtained results prove that for ¹⁸⁸Re binding with KNaHEDP with the efficiency not less than 95 % the optimum concentration of stable rhenium in the reaction mixture is 0.54×10⁻⁶ mol·ml⁻¹ (0.1 mgMl⁻¹) and the ratio of Re⁷⁺: Sn²⁺ concentrations should not be lower than 10: 1.