Skip to main content
SpringerLink
Log in

Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes

  • Published:
Czechoslovak Journal of Physics Aims and scope

Abstract

This paper summarizes results achieved in labelling texaphyrin with radionuclides (e.g., with 177Lu) and characterization of the metal-texaphyrin complexes. Thin layer chromatography (TLC) method was used for the quality control of the 177Lu-labeled texaphyrin. Thermal analysis, mass spectroscopy (MS) and Fourier transform infrared spectroscopy (FT-IR) were used for the characterization of the Ca-texaphyrin, Lu-texaphyrin and Y-texaphyrin. The chemical and physical properties depend on the metal centrally placed into the cavity of the texaphyrin molecule. The labelling yield of the 177Lu-texaphyrin by the neutron irradiated Lu-Tex complex in the LVR-15 reactor was determined to be 40 %. The TLC technique is suitable for the separation of the 177Lu-Tex complex from the radionuclide 177Lu. The fact that texaphyrin exhibits a high affinity of bonding to cancer cells is of great advantage as no antibody has to be applied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sessler J. L. et al.: Acc. Chem. Res. 27 (1994) 43.

    Article  Google Scholar 

  2. Hannah S. et al.: J. Am. Chem. Soc. 124 (2002) 8416.

    Article  Google Scholar 

  3. Carde P. et al.: J. Clin. Onc. 19 (2001) 2074.

    Google Scholar 

  4. Sessler J. L. et al.: J. Am. Chem. Soc. 115 (1993) 10368.

  5. Sessler J. L. et al.: J. Alloys Compd. 249 (1997) 146.

    Article  Google Scholar 

  6. Young S. W. et al.: Photochem. Photobiol. 63 (1996) 829.

    Google Scholar 

  7. Sessler J. L. and Miller R. A.: Biochem. Pharmacol. 59 (2000) 733.

    Article  Google Scholar 

  8. Magda D. J. et al.: J Am. Chem. Soc. 117 (1995) 3629.

    Article  Google Scholar 

  9. Kubát P., Lang K., Zelinger Z., and Král V.: J. Inorg. Biochem. 99 (2005) 1670.

    Article  Google Scholar 

  10. Magda D., Miller R. A., Sessler, J. L., and Iverson B. L.: J. Am. Chem. Soc. 116 (1994) 7439.

    Article  Google Scholar 

  11. Kostenich G. et al.: J. Photochem. Photobiol. B 39 (1997) 36.

    Article  Google Scholar 

  12. Sessler J. L., Mody T. D. Hemmi G. W., and Lynch V.: Inorg. Chem. 32 (1993) 3175.

    Article  Google Scholar 

  13. Sessler J. L. et al.: Acc. Chem. Res. 27 (1994) 43.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Analytical Chemistry, Institute of Chemical Technology, Technická 5, 166-28, Prague 6, Czech Republic

    M. Reková, V. Král & V. Jedináková-KřÍžová

Authors
  1. M. Reková
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Král
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Jedináková-KřÍžová
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reková, M., Král, V. & Jedináková-KřÍžová, V. Characterization of metal-texaphyrin complexes and preparation of radionuclide-texaphyrin complexes. Czech J Phys 56 (Suppl 4), D719–D729 (2006). https://doi.org/10.1007/s10582-006-0571-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10582-006-0571-y

Keywords

Search

Navigation