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Czechoslovak Journal of Physics

, Volume 56, Supplement 4, pp D23–D34 | Cite as

Hybrid gold nanoparticles in molecular imaging and radiotherapy

  • K. V. Katti
  • R. Kannan
  • K. Katti
  • V. Kattumori
  • R. Pandrapraganda
  • V. Rahing
  • C. Cutler
  • E. J. Boote
  • S. W. Casteel
  • C. J. Smith
  • J. D. Robertson
  • S. S. Jurrison
Article

Abstract

Metallic nanoparticles, because of their size, chemical and physical properties, are particularly attractive as therapeutic probes in treating cancer. Central to any clinical advances in nanoparticulate based therapy will be to produce hybrid nanoparticles that can be targeted to vascular, extracellular or cell surface receptors. Development of hybrid nanoparticles that specifically target cancer vasculature has received considerable attention. Most cancers have leaky vasculature and the defective vascular architecture, created due to the rapid vascularization necessary to serve fast growing cancers, in combination with poor lymphatic drainage allows increased permeation and retention effects. The leaky vasculature, because of higher porosity and permeability, serve as natural high affinity targets to metallic nanoparticles. Another attractive approach toward the application of nanotechnology to nanomedicine is the utility of nanoparticles that display inherent therapeutic properties. For example radioactive gold nanoparticles present attractive prospects in therapy of cancer. The radioactive properties of Au-198 (βmax = 0.96 MeV; t1/2 = 2.7 d) and Au-199 (βmax = 0.46 MeV; t1/2 = 3.14 d) make them ideal candidates for use in radiotherapeutic applications. In addition, they both have imageable gamma emissions for dosimetry and pharmacokinetic studies and Au-199 can be made carrier-free by indirect methods. Gold nanoparticles are of interest for treatment of disease as they can deliver agents directly into cells and cellular components with a higher concentration of radioactivity, e.g. higher dose of radioactivity, to cancerous tumor cells.

Keywords

Gold Nanoparticles PAMAM Dendrimers Hybrid Nanoparticles Cancerous Tumor Cell Tumor Microvasculature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    Balogh L., Nigavekar S. S., Cook A. T., Minc L., and Khan M. K.: Abstracts of Papers of the American Chemical Society 225 (2003) U270.Google Scholar
  2. [2]
    Bielinska A., Eichman J. D., Lee I., Baker J. R., and Balogh L.: Journal of Nanoparticle Research 4 (2002) 395.CrossRefGoogle Scholar
  3. [3]
    Nigavekar S. S., Balogh L. P., Cook A. C., Minc L. and Khan M. K.: PharmaChem (2003) 94–99.Google Scholar
  4. [4]
    J. F. Hainfeld, D. N. Slatkin, and H. M. Smilowitz: Physics in Medicine and Biology 49 (2004) N309–N315.CrossRefGoogle Scholar
  5. [5]
    Hainfeld J. F. and Powell R. D.: Journal of Histochemistry & Cytochemistry 48 (2000) 471.Google Scholar
  6. [6]
    Hainfeld J. F. and Robinson J. M.: Journal of Histochemistry & Cytochemistry 48 (2000) 459.Google Scholar
  7. [7]
    Hainfeld J.F., Powell R. D., and Hacker G.W.: Nanobiotechnology (Eds. C. M. Niemeyer and Mirkin, C.A.), Wiley-Vch, Germany, 2004 p. 353–386.CrossRefGoogle Scholar
  8. [8]
    Dilmanian F. A., Morris G. M., Zhong N., Bacarian T., Hainfeld J. F., Kalef-Ezra J., Brewington L. J., Tammam J., and Rosen E. M.: Radiation Research 159 (2003) 632.CrossRefGoogle Scholar
  9. [9]
    Billinghurst M.: In: Radiolabeled and Magnetic Particulates in Medicine & Biology; Vol. 3, edited by R. Arshady (2001), p. 149–76.Google Scholar
  10. [10]
    Alfonso A., Hassan A., Gardner B., Stein S., Patti J., Solomon N., McCarthy J., and Steigman J.: Cancer Res 38 (1978) 2740.Google Scholar
  11. [11]
    Ashamalla R. S. H., Zaki B, Ikoro N.C., Ross P.: Brachytherapy 1 (2002) 161.CrossRefGoogle Scholar
  12. [12]
    Emery J. F., Leddicotte G. W., Radiochemistry of Gold ((National Academy of Sciences—National Research Council) NAS-NS-3036, 1961).Google Scholar

Copyright information

© Institute of Physics, Academy of Sciences of Czech Republic 2006

Authors and Affiliations

  • K. V. Katti
    • 1
    • 2
  • R. Kannan
    • 1
    • 2
  • K. Katti
    • 1
    • 2
  • V. Kattumori
    • 1
    • 2
  • R. Pandrapraganda
    • 1
    • 2
  • V. Rahing
    • 1
    • 2
  • C. Cutler
    • 1
    • 2
  • E. J. Boote
    • 1
    • 2
  • S. W. Casteel
    • 1
    • 2
  • C. J. Smith
    • 1
    • 2
  • J. D. Robertson
    • 1
    • 2
  • S. S. Jurrison
    • 1
    • 2
  1. 1.Departments of Radiology, Physics and ChemistryMissouri University Research ReactorColumbiaUSA
  2. 2.Veterans AffairsUniversity of Missouri-ColumbiaColumbiaUSA

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