Abstract
Intracranial aneurysms are reported to affect 2–5% of the population. Despite advances in the surgical management of this disease, diagnostic technologies have marginally improved and still rely on expensive or invasive imaging procedures. Currently, there is no blood-based test to detect cerebral aneurysm formation or quantify the risk of rupture. The aim of this review is to summarize current literature on the mechanism of aneurysm formation, specifically studies relating to inflammation, and provide a rationale and commentary on a hypothetical future blood-based test. Efforts should be focused on clinical-translational approaches to create an assay to screen for cerebral aneurysm presence and risk-stratify patients to allow for superior treatment timing and management.
Graphical Abstract
Cerebral Aneurysm Blood Test Considerations: There are multiple caveats to development of a putative blood test to detect cerebral aneurysm presence.
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KWN and AM conceived the study, interpreted and analyzed data, and drafted the manuscript. HAS and EKR participated in drafting and editing the manuscript. EKR designed and created figures for the manuscript. MJL, BAG, and RMF participated in designing the study, interpreting data and drafting the manuscript. All authors read and approved the final manuscript.
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Nowicki, K.W., Mittal, A.M., Abou-Al-Shaar, H. et al. A Future Blood Test to Detect Cerebral Aneurysms. Cell Mol Neurobiol 43, 2697–2711 (2023). https://doi.org/10.1007/s10571-023-01346-4
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DOI: https://doi.org/10.1007/s10571-023-01346-4