Abstract
Diabetes is a common metabolic disease characterized by loss of blood sugar control and a high rate of complications. γ-Aminobutyric acid (GABA) functions as the primary inhibitory neurotransmitter in the adult mammalian brain. The normal function of the GABAergic system is affected in diabetes. Herein, we summarize the role of the GABAergic system in diabetic cognitive dysfunction, diabetic blood sugar control disorders, diabetes-induced peripheral neuropathy, diabetic central nervous system damage, maintaining diabetic brain energy homeostasis, helping central control of blood sugar and attenuating neuronal oxidative stress damage. We show the key regulatory role of the GABAergic system in multiple comorbidities in patients with diabetes and hope that further studies elucidating the role of the GABAergic system will yield benefits for the treatment and prevention of comorbidities in patients with diabetes.
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Funding
The work was supported by Grants from the National Natural Science Foundation of China (No. 81770806), the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0249), and Special Project for Enhancing Science and Technology Innovation Ability of Army Medical University (No. 2019XYY16, 2021-2018-062).
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Zhou, H., Rao, Z., Zhang, Z. et al. Function of the GABAergic System in Diabetic Encephalopathy. Cell Mol Neurobiol 43, 605–619 (2023). https://doi.org/10.1007/s10571-022-01214-7
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DOI: https://doi.org/10.1007/s10571-022-01214-7