Abstract
Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible visual damage. Long non-coding RNAs (lncRNAs), which belong to the family of non-protein-coding transcripts, have been linked to the pathogenesis, progression, and prognosis of these lesions. Retinal ganglion cells (RGCs) are critical for the transmission of visual information to the brain, damage to which results in visual loss. Apoptosis has been identified as one of the most essential modes of RGC death. Emerging evidence suggests that lncRNAs can regulate RGC degeneration by directly or indirectly modulating apoptosis-associated signaling pathways. This review presents a comprehensive overview of the role of lncRNAs in RGC apoptosis at transcriptional, post-transcriptional, translational, and post-translational levels, emphasizing on the potential mechanisms of action. The current limitations and future perspectives of exploring the connection between lncRNAs and RGC apoptosis have been summarized. Understanding the intricate molecular interaction network of lncRNAs and RGC apoptosis will open new avenues for the identification of novel diagnostic biomarkers, therapeutic targets, and molecules for prognostic evaluation of diseases related to RGC injury.
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This work was supported by the Provincial Natural Science Foundation of Hubei Province (grant number 2020CFB240) and the Fundamental Research Funds for the Central Universities (grant number 2042020kf0065).
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This work was supported by the Provincial Natural Science Foundation of Hubei Province (Grant Number 2020CFB240) and the Fundamental Research Funds for the Central Universities (Grant Number 2042020kf0065).
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NZ and NY conceived and initiated this review. NZ wrote the first draft of this manuscript. WC and XH collected and archived the related literature. YX, and NY revised, formatted, and edited the manuscript. All authors read and approved the final version of the manuscript for publication.
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Zhang, N., Cao, W., He, X. et al. Long Non-Coding RNAs in Retinal Ganglion Cell Apoptosis. Cell Mol Neurobiol 43, 561–574 (2023). https://doi.org/10.1007/s10571-022-01210-x
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DOI: https://doi.org/10.1007/s10571-022-01210-x