Abstract
The circadian clock is a biochemical oscillator that is synchronized with solar time. Normal circadian rhythms are necessary for many physiological functions. Circadian rhythms have also been linked with many physiological functions, several clinical symptoms, and diseases. Accumulating evidence suggests that the circadian clock appears to modulate the processing of nociceptive information. Many pain conditions display a circadian fluctuation pattern clinically. Thus, the aim of this review is to summarize the existing knowledge about the circadian clocks involved in diurnal rhythms of pain. Possible cellular and molecular mechanisms regarding the connection between the circadian clocks and pain are discussed.
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References
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Funding
This work was funded by the National Natural Science Foundation of China, Grant Numbers 81870737 and 81771098; Natural Science Foundation of Guangdong Province, Grant Number 2021A1515011779, and Guangdong Financial Fund for High-Caliber Hospital Construction, Grant Number 174-2018-XMZC-0001-03-0125/D-02.
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Conceptualization, YC; writing—original draft preparation, YC; writing—review and editing, YC and HH; preparation of figures and tables, QL and SJ; supervision, WF and FH. All authors have read and agreed to the published version of the manuscript.
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Chu, Y., He, H., Liu, Q. et al. The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain. Cell Mol Neurobiol 43, 511–523 (2023). https://doi.org/10.1007/s10571-022-01205-8
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DOI: https://doi.org/10.1007/s10571-022-01205-8