Skip to main content

The Roles of Serotonin in Neuropsychiatric Disorders

Abstract

The serotonergic system extends throughout the central nervous system (CNS) and the gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a broad spectrum of functions, including mood, cognition, anxiety, learning, memory, reward processing, and sleep. These processes are mediated through 5-HT binding to 5-HT receptors (5-HTRs), are classified into seven distinct groups. Deficits in the serotonergic system can result in various pathological conditions, particularly depression, schizophrenia, mood disorders, and autism. In this review, we outlined the complexity of serotonergic modulation of physiologic and pathologic processes. Moreover, we provided experimental and clinical evidence of 5-HT’s involvement in neuropsychiatric disorders and discussed the molecular mechanisms that underlie these illnesses and contribute to the new therapies.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Reza Ahadi or Mohammad Taghi Joghataei.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest regarding the publication of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Pourhamzeh, M., Moravej, F.G., Arabi, M. et al. The Roles of Serotonin in Neuropsychiatric Disorders. Cell Mol Neurobiol 42, 1671–1692 (2022). https://doi.org/10.1007/s10571-021-01064-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10571-021-01064-9

Keywords

  • 5-HT
  • SSRI
  • Mood Disorders
  • Nervous System Diseases
  • Serotonin pathway