Abstract
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C—IL-1β (rs1143623), c. -118 C > T—IL-1β (rs1143627), c.340G > T—IL-1α (rs17561), c.-1211T > C—TNF-α (rs1799964) and c.-488G > A—TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene–gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.
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Funding
This study was funded by Polish National Science Centre UMO-2015/19/BNZ7/00410.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Katarzyna Białek, Piotr Czarny, Cezary Watała, Ewelina Synowiec, Paulina Wigner, Michał Bijak, Monika Talarowska, Piotr Galecki, Janusz Szemraj, and Tomasz Sliwinski. The first draft of the manuscript was written by Katarzyna Białek, Piotr Czarny, Cezary Watała, Tomasz Sliwinski and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All procedures was approved by the Bioethics Committee of the Medical University of Lodz (No. RNN/70/14/KE).
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Informed consent was obtained from all individual participants included in the study and was approved by the Bioethics Committee of the Medical University of Lodz (No. RNN/70/14/KE).
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Bialek, K., Czarny, P., Watala, C. et al. Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder. Cell Mol Neurobiol 40, 1049–1056 (2020). https://doi.org/10.1007/s10571-019-00782-5
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DOI: https://doi.org/10.1007/s10571-019-00782-5