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Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-β-SOX9 Signaling Pathway

  • Jiaying Yuan
  • Benson O. A. Botchway
  • Yong Zhang
  • Xiaoning Tan
  • Xizhi Wang
  • Xuehong LiuEmail author
Review Paper

Abstract

Spinal cord injury (SCI) is a severe nervous system disease with high morbidity and disability rate. Signaling pathways play a key role in the neuronal restorative mechanism following SCI. SRY-related high mobility group (HMG)-box gene 9 (SOX9) affects glial scar formation via Transforming growth factor beta (TGF-β) signaling pathway. Activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is transferred into nucleus to upregulate TGF-β-SOX9. Curcumin exhibits potent anti-inflammatory and anti-oxidant properties. Curcumin can play an important role in SCI recovery by inhibiting the expression of NF-κB and TGF-β-SOX9. Herein, we review the potential mechanism of curcumin-inhibiting SOX9 signaling pathway in SCI treatment. The inhibition of NF-κB and SOX9 signaling pathway by curcumin has the potentiality of serving as neuronal regenerative mechanism following SCI.

Keywords

Curcumin SOX9 signaling pathway NF-κB signaling pathway Spinal cord injury Neuroregeneration Anti-oxidation Anti-inflammation 

Notes

Author contributions

XL designed the study. JY, BOAB, YZ, XT, XW and XL prepared the first draft of the manuscript. JY, BOAB, YZ, and XL revised the manuscript. All authors approved the final paper.

Funding

This work was supported by the Natural Science Foundation of Zhejiang Province (No. LY19H170001) and Public Technology Applied Research Projects Foundation of Shaoxing City (No. 2017B70066).

Compliance with Ethical Standards

Conflict of interest

None to declare.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Jiaying Yuan
    • 1
  • Benson O. A. Botchway
    • 2
  • Yong Zhang
    • 1
  • Xiaoning Tan
    • 2
  • Xizhi Wang
    • 1
  • Xuehong Liu
    • 1
    Email author
  1. 1.Department of Histology and Embryology, Medical CollegeShaoxing UniversityShaoxingChina
  2. 2.Institute of NeuroscienceZhejiang University School of MedicineHangzhouChina

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