Abstract
Glioblastoma, one of the common malignant brain tumors, results in the highly death, but its underlying molecular mechanisms remain unclear. Smurf1, a member of Nedd4 family of HECT-type ligases, has been reported to contribute to tumorigenicity through several important biological pathways. Recently, it was also found to participate in modulate cellular processes, including morphogenesis, autophagy, growth, and cell migration. In this research, we reported the clinical guiding significance of the expression of Smurf1 in human glioma tissues and cell lines. Western blotting analysis discovered that the expression of Smurf1 was increased with WHO grade. Immunohistochemistry levels discovered that high expression of Smurf1 is closely consistent with poor prognosis of glioma. In addition, suppression of Smurf1 can reduce cell invasion and increase the E-cadherin expression, which is a marker of invasion. Our study firstly demonstrated that Smurf1 may promote glioma cell invasion and suppression of the Smurf1 may provide a novel treatment strategy for glioma.
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Acknowledgements
Clinical Special Science Fund of Science and Technology of Jiangsu Province provided financial support in the form of No. BL2013006 funding. “The Six-Talent Peak” Fund of Jiangsu Province provided financial support in the form of No. WSW-063 funding. “333 High-level Personnel Training Project” Fund of Jiangsu Province provided financial support in the form of No. BRA2015051 funding. The sponsor had no role in the design or conduct of this research.
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Chang, H., Zhang, J., Miao, Z. et al. Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas. Cell Mol Neurobiol 38, 421–430 (2018). https://doi.org/10.1007/s10571-017-0485-1
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DOI: https://doi.org/10.1007/s10571-017-0485-1