Skip to main content

Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma

Cellular and Molecular Neurobiology volume 37, pages 37–42 (2017)Cite this article

Abstract

Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis and limited treatment options. Tumor suppressor candidate 1 (TUSC1) was recently identified as a potential tumor suppressor in human cancers. However, the expression and potential function of TUSC1 in GBM remain unclear. Herein, we report that TUSC1 is significantly decreased in GBM tissues and cell lines. Patients with high levels of TUSC1 displayed a significant better survival compared with those with low levels of TUSC1. Functional experiments demonstrated that exogenous expression of TUSC1 inhibited GBM cell proliferation and induced G1 phase arrest by down-regulating CDK4. Moreover, overexpression of TUSC1 retarded tumor growth in vivo. Together, our findings revealed that TUSC1 might be a crucial tumor suppressor gene and a novel therapeutic target for GBM.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81201978, No. 81372709), the Jiangsu Province’s Natural Science Foundation (BK2012483), the Program for Advanced Talents within Six Industries of Jiangsu Province (2012-WSN- 019), and Science and technology development foundation of Nanjing Medical University (2014NJMUZD080).

Author information

Author notes

    Affiliations

    1. Department of Neurosurgery, Nanjing Children’s Hospital, Affiliated to Nanjing Medical University, Nanjing, 210029, China

      Rui Zhang, Zhanjun Jia & Gang Wang

    2. Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

      Rui Zhang, Zhengxin Chen, Lin Zhao, Ning Liu & Huibo Wang

    3. Hospital of Integrated Traditional Chinese and Western Medicine in Jiangsu Province, Nanjing, 210029, China

      Wan Yu

    4. The Institute of Pediatrics, Affiliated to Nanjing Medical University, Nanjing, 210029, China

      Guanyu Liang & Aihua Zhang

    5. Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

      Yongsheng Yuan

    6. Department of Microbiology & Immunology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

      Xiaobin Zhou

    7. Department of Laboratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China

      Daqian Li

    8. The Institute of Biochemistry, Zhejiang University, Hangzhou, 310058, China

      Shuying Shen

    9. Chinese Glioma Cooperative Group (CGCG), Beijing, China

      Ning Liu & Huibo Wang

    Authors
    1. Rui Zhang
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Wan Yu
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Guanyu Liang
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Zhanjun Jia
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Zhengxin Chen
      View author publications

      You can also search for this author in PubMed Google Scholar

    6. Lin Zhao
      View author publications

      You can also search for this author in PubMed Google Scholar

    7. Yongsheng Yuan
      View author publications

      You can also search for this author in PubMed Google Scholar

    8. Xiaobin Zhou
      View author publications

      You can also search for this author in PubMed Google Scholar

    9. Daqian Li
      View author publications

      You can also search for this author in PubMed Google Scholar

    10. Shuying Shen
      View author publications

      You can also search for this author in PubMed Google Scholar

    11. Ning Liu
      View author publications

      You can also search for this author in PubMed Google Scholar

    12. Aihua Zhang
      View author publications

      You can also search for this author in PubMed Google Scholar

    13. Huibo Wang
      View author publications

      You can also search for this author in PubMed Google Scholar

    14. Gang Wang
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding authors

    Correspondence to Huibo Wang or Gang Wang.

    Ethics declarations

    Conflict of interest

    The authors declare no conflict of interest.

    Additional information

    Rui Zhang and Wan Yu have contributed equally to the work.

    Electronic supplementary material

    Below is the link to the electronic supplementary material.

    Supplementary material 1 (DOCX 221 kb)

    Rights and permissions

    Reprints and Permissions

    About this article

    Verify currency and authenticity via CrossMark

    Cite this article

    Zhang, R., Yu, W., Liang, G. et al. Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts Better Survival in Glioblastoma. Cell Mol Neurobiol 37, 37–42 (2017). https://doi.org/10.1007/s10571-016-0339-2

    Download citation

    • Received:

    • Accepted:

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s10571-016-0339-2

    Keywords

    • Glioblastoma
    • Proliferation
    • Tumor suppressor
    • TUSC1