Cellular and Molecular Neurobiology

, Volume 36, Issue 3, pp 353–360 | Cite as

ExRNA in Biofluids as Biomarkers for Brain Tumors

  • Robert C. Rennert
  • Fred H. Hochberg
  • Bob S. Carter
Review Paper

Abstract

Patients with high-grade gliomas and glioblastomas (GBMs) have poor survival despite optimal surgical and drug therapy. Minimally invasive diagnostic biomarkers would enable early diagnosis and tumor-specific treatments for ‘personalized targeted’ therapy, and would create the basis for response tracking in patients with GBM. Extracellular vesicles (EVs) isolated from cerebrospinal fluid and blood contain glioma-specific molecules, including tumor-derived EV RNAs that are detectable in small copy numbers in these biofluids. EV RNA mutations or expression changes are also detectable, the analysis of which gives rise to ‘liquid biopsy’ tumor profiling.

Keywords

Glioma Glioblastoma Extracellular vesicle RNA 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Robert C. Rennert
    • 1
  • Fred H. Hochberg
    • 1
  • Bob S. Carter
    • 1
  1. 1.Department of NeurosurgeryUniversity of California – San DiegoSan DiegoUSA

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