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Nuclear Factor One X Regulates Bobby Sox During Development of the Mouse Forebrain

Cellular and Molecular Neurobiology volume 33, pages 867–873 (2013)Cite this article

Abstract

The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix −/− mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.

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Acknowledgements

We thank Kathleen Cato for technical assistance and Rowan Tweedale and Linda Richards for critical analysis of the manuscript. This work was funded by the National Health and Medical Research Council (NHMRC) Project Grants (Grant Numbers 1022308, 1003462; MP) and by awards from the NYSTEM (C026429; RMG) and the NIH (HL 080624; RMG). MP was supported by an Australian Research Council Future Fellowship.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Affiliations

  1. The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia

    Chantelle Dixon, Tracey J. Harvey, Aaron G. Smith & Michael Piper

  2. Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia

    Michael Piper

  3. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia

    Timothy L. Bailey

  4. Developmental Genomics Group, Department of Biochemistry and the Program in Neuroscience New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY, USA

    Richard M. Gronostajski

Authors
  1. Chantelle Dixon
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  2. Tracey J. Harvey
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  3. Aaron G. Smith
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  4. Richard M. Gronostajski
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  5. Timothy L. Bailey
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  6. Michael Piper
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Corresponding author

Correspondence to Michael Piper.

Additional information

Chantelle Dixon and Tracey J. Harvey have contributed equally to this work.

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Dixon, C., Harvey, T.J., Smith, A.G. et al. Nuclear Factor One X Regulates Bobby Sox During Development of the Mouse Forebrain. Cell Mol Neurobiol 33, 867–873 (2013). https://doi.org/10.1007/s10571-013-9961-4

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  • DOI: https://doi.org/10.1007/s10571-013-9961-4

Keywords

  • Bobby sox
  • Nuclear factor one X
  • Neural progenitor cell
  • Transcription factor