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Adrenomedullary Response to Glucagon in Patients with Primary Sjögren’s Syndrome

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Abstract

Several studies showed signs of autonomic dysfunction in patients with primary Sjögren’s syndrome (pSS). Adrenomedullary function might be of importance for pSS pathogenesis by affecting salivary gland functions and modulating immune responses. The aim of the study was to evaluate the adrenomedullary hormonal system in patients with pSS. The glucagon test (1 mg i.v.) was performed in 18 pSS patients and 13 control subjects. During the test each patient had electrocardiographic and impedance cardiographic monitoring. Plasma epinephrine and norepinephrine were assayed by liquid chromatography with electrochemical detection after batch alumina extraction. Baseline concentrations of epinephrine and norepinephrine were comparable between pSS and controls. Glucagon administration induced a significant increase in systolic blood pressure, diastolic blood pressure, heart rate, cardiac output (P < 0.01), and stroke volume; however, the changes were comparable between pSS and controls. Epinephrine levels increased (P < 0.01) in response to glucagon administration while norepinephrine concentration did not change. There was no significant difference in neurochemical responses to glucagon between pSS and controls. In conclusion, the present results suggest normal adrenomedullary function in pSS.

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Acknowledgment

The research project was supported by the intramural research programs of the National Institute of Dental and Craniofacial Research and the National Institute of Neurological Disorders and Stroke.

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Authors and Affiliations

  1. Center for Molecular Medicine, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3-7, 831 01, Bratislava, Slovak Republic

    Richard Imrich

  2. Sjögren’s Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA

    Nikolay P. Nikolov, Lolita Bebris, Ilias Alevizos & Gabor G. Illei

  3. Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA

    David S. Goldstein & Courtney S. Holmes

Authors
  1. Richard Imrich
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  2. Nikolay P. Nikolov
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  3. Lolita Bebris
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  4. Ilias Alevizos
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  5. David S. Goldstein
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  6. Courtney S. Holmes
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  7. Gabor G. Illei
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Correspondence to Gabor G. Illei.

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Imrich, R., Nikolov, N.P., Bebris, L. et al. Adrenomedullary Response to Glucagon in Patients with Primary Sjögren’s Syndrome. Cell Mol Neurobiol 32, 903–906 (2012). https://doi.org/10.1007/s10571-011-9787-x

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  • DOI: https://doi.org/10.1007/s10571-011-9787-x

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