Abstract
Discs-large-related 3 (DLG3), a member of the membrane-associated guanylate kinases (MAGUKs) protein family, playing an important role in regulating NMDA signal pathway and contributing to synaptic plasticity, may have an influence on the susceptibility of non-syndromic mental retardation (NSMR). To investigate the possible genetic contribution of DLG3 gene to the NSMR of Chinese Han population, we performed an association study of 556 subjects (118 NSMR, 116 borderline NSMR, and 322 controls in 275 males and 281 females) from Qin-Ba mountain region of Shaanxi province in the northwest of China by five common SNPs in the gene. The results showed that there was no positive association between the genetic variations of DLG3 and NSMR. In conclusion, the results of this study indicated that DLG3 did not associate with NSMR in Chinese Han population; however, further studies are needed.
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Acknowledgments
The authors would like to thank all the participants and researchers in this study, in respect of their invaluable discussions and critical comments. This study was supported by grants from the National Key Technology Research and Development Program of China during the “10th Five-Year Plan” (2001BA901A49), and the Key Science and Technology Program of Shaanxi Province, China (2009K01-58).
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Han, N., Shi, Z., Zhang, K. et al. Polymorphisms in the DLG3 Gene is not Associated with Non-Syndromic Mental Retardation in the Chinese Han Population of Qin-Ba Mountain. Cell Mol Neurobiol 31, 695–700 (2011). https://doi.org/10.1007/s10571-011-9666-5
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DOI: https://doi.org/10.1007/s10571-011-9666-5