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Lipid Dynamics in Exocytosis

Cellular and Molecular Neurobiology volume 30, pages 1335–1342 (2010)Cite this article

Abstract

Regulated exocytosis of neurotransmitter- and hormone-containing vesicles underpins neuronal and hormonal communication and relies on a well-orchestrated series of molecular interactions. This in part involves the upstream formation of a complex of SNAREs and associated proteins leading to the eventual fusion of the vesicle membrane with the plasma membrane, a process that enables content release. Although the role of lipids in exocytosis is intuitive, it has long been overlooked at least compared to the extensive work on SNAREs. Here, we will present the latest advances in this rapidly developing field revealing that lipids actually play an active role in exocytosis by focusing on cholesterol, 3′-phosphorylated phosphoinositides and phosphatidic acid.

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Fig. 1

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Acknowledgment

We want to thank the members of our laboratories and the collaborators who contributed to the work presented here. We wish to thank Dr Nancy Grant for critical reading of the manuscript. Work in NV’s group is supported by Agence Nationale pour la Recherche (ANR-09-BLAN-0264-01 grant). JRC acknowledges support of the CIHR, NSERC, and the University of Western Sydney.

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Affiliations

  1. Département Neurotransmission & Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives (UPR-3212), Centre National de la Recherche Scientifique, Université de Strasbourg, 5 rue Blaise Pascal, 67084, Strasbourg, France

    S. Chasserot-Golaz & N. Vitale

  2. Department of Molecular Physiology, School of Medicine and Molecular Medicine Research Group and Nanoscale Organization and Dynamics Group, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW, 1797, Australia

    J. R. Coorssen

  3. Neuronal Trafficking Laboratory, Queensland Brain Institute, University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia

    F. A. Meunier

Authors
  1. S. Chasserot-Golaz
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  2. J. R. Coorssen
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  3. F. A. Meunier
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  4. N. Vitale
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Corresponding author

Correspondence to N. Vitale.

Additional information

A commentary to this article can be found at doi:10.1007/s10571-010-9610-0.

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Chasserot-Golaz, S., Coorssen, J.R., Meunier, F.A. et al. Lipid Dynamics in Exocytosis. Cell Mol Neurobiol 30, 1335–1342 (2010). https://doi.org/10.1007/s10571-010-9577-x

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  • DOI: https://doi.org/10.1007/s10571-010-9577-x

Keywords

  • Cholesterol
  • Chromaffin cells
  • Exocytosis
  • Phosphatidic acid
  • Phosphoinositide