Skip to main content

Advertisement

Log in

Drug Abuse in China: Past, Present and Future

  • Original Paper
  • Published:
Cellular and Molecular Neurobiology Aims and scope Submit manuscript

An Erratum to this article was published on 15 November 2009

Abstract

Following British importation of opium to China in 1760s, the use and production of the drug in China increased dramatically. This situation was aggravated after the failure of Opium Wars that occurred between the United Kingdom and the Qing Empire in China with the aim of forcing China to import British Opium; this war made China open the door to a free flowing opium trade, with disastrous social and public health consequences. The subsequent rise of the new China created drug-free atmosphere by strict legislation and punishment, in which drug use greatly decreased. However, in the context of governmental reform and the open-door policies of the 1980s, drug abuse has re-emerged as a major public health problem. Today, drug abuse is highly linked to the spread of HIV/AIDS and to drug-related crimes in China. To combat the severe drug problem facing the nation, the Chinese government has adopted the Methadone Maintenance Treatment program, a multi-faceted therapeutic approach that aims to reduce the health and social problem induced by drug epidemics. In addition, traditional Chinese medicine, including herbal therapy and acupuncture, both found to be effective in the prevention of relapse and causes few side effects, making them useful for the treatment of opiate addiction. With continuous application of these therapies and managements that have been proved to be effective in harm reduction in the western countries, we believe that drug abuse and its related problems in China will be brought under control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  • Aceijas C, Stimson GV, Hickman M, Rhodes T (2004) Global overview of injecting drug use and HIV infection among injecting drug users. Aids 18(17):2295–2303

    Google Scholar 

  • Bai Y (2001) The anti-opium campaign movement in the early 1950s. CPC History 10:38

    Google Scholar 

  • Bureau for International Narcotics and Law Enforcement Affairs (2003) International narcotics control strategy report – 2003: Southeast Asia and the Pacific. The Bureau for International Narcotics and Law Enforcement Affairs

  • Carroll KM, Ball SA, Nich C, Martino S, Frankforter TL, Farentinos C, Kunkel LE, Mikulich-Gilbertson Sk, Morgenstern J, Obert JL, Polcin D, Snead N, Woody GE (2006) Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: a multisite effectiveness study. Drug Alcohol Depend 81:301–312

    Article  PubMed  Google Scholar 

  • China National Narcotics Control Commission (2002) Annual report on drug control in China. China National Narcotics Control Commission (NNCC), Beijing

  • China-UK Workshop on HIV/AIDS (2002) Annual report of China–UK HIV/AIDS Prevention and Care Project. China–UK Workshop on HIV/AIDS in China, Beijing

  • Clement JV, McLoughlin L, Lowry PJ, Besser GM, Rees LH, Wen HL (1979) Acupuncture in heroin addicts; changes in Met-enkephalin and beta-endorphin in blood and cerebrospinal fluid. Lancet 2:380–383

    Google Scholar 

  • Fang YX, Wang YB, Shi J, Liu ZM, Lu L (2006) Recent trends in drug abuse in China. Acta Pharmacol Sin 27:140–144

    Article  CAS  PubMed  Google Scholar 

  • Fok MS, Tsang WY (2005) Development of an instrument measuring Chinese adolescent beliefs and attitudes towards substance abuse. J Clin Nurs 14:986–994

    Article  PubMed  Google Scholar 

  • Hao W, Xiao S, Liu T, Young D, Chen S, Zhang D, Li C, Shi J, Chen G, Yang K (2002) The second National Epidemiological Survey on illicit drug use at six high-prevalence areas in China: prevalence rates and use patterns. Addiction 97:1305–1315

    Article  PubMed  Google Scholar 

  • Hao W, Young D, Li L, Xiao S (1998) Psychoactive substance use in three sites in China: gender differences and related factors. Psychiatry Clin Neurosci 52(Suppl):S324–S328

    PubMed  Google Scholar 

  • Kaufman J, Jing J (2002) China and AIDS: the time to act is now. Science 296:2339–2340

    Article  CAS  PubMed  Google Scholar 

  • Kerr C (2005) Sexual transmission propels China’s HIV epidemic. Lancet Infect Dis 5:474

    Article  PubMed  Google Scholar 

  • Konefal J, Duncan R, Clemence C (1994) The impact of the addition of an acupuncture treatment program to an existing metro-Dade County outpatient substance abuse treatment facility. J Addict Dis 13:71–99

    Article  CAS  PubMed  Google Scholar 

  • Krishnan-Sarin S, Jing SL, Kurtz DL, Zweifel M, Portoghese PS, Li TK, Froehlich JC (1995) The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference. Psychopharmacology 120:177–185

    Article  CAS  PubMed  Google Scholar 

  • Lau JT, Feng T, Lin X, Wang Q, Tsui HY (2005) Needle sharing and sex-related risk behaviours among drug users in Shenzhen, a city in Guangdong, southern China. AIDS Care 17:166–181

    Article  CAS  PubMed  Google Scholar 

  • Li Z, Xu NJ, Wu CF, Xiong Y, Fan HP, Zhang WB, Sun Y, Pei G (2001) Pseudoginsenoside-F11 attenuates morphine-induced signalling in Chinese hamster ovary-mu cells. Neuroreport 12:1453–1456

    Article  CAS  PubMed  Google Scholar 

  • Lintzeris N, Drugs NeACoI, Ageing ADoHa, Stratrgy Nd (2006) National clinical guidelines and procedures for the use of buprenorphine. Dept. of Health and Ageing, Canberra

  • Lowinger P (1973) How the People’s Republic of China solved the drug abuse problem. Am J Chin Med 1:275–282

    Article  CAS  PubMed  Google Scholar 

  • Lowinger P (1977) The solution to narcotic addiction in the People’s Republic of China. Am J Drug Alcohol Abuse 4:165–178

    Article  CAS  PubMed  Google Scholar 

  • Maas LC, Lukas SE, Kaufman MJ, Weiss RD, Daniels SL, Rogers VW, Kukes TJ, Renshaw PF (1998) Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry 155:124–126

    CAS  PubMed  Google Scholar 

  • McCoy CB, Lai S, Metsch LR, Wang X, Li C, Yang M, et al. (1997) No pain no gain: establishing the Kunming, China, drug rehabilitation center. J Drug Issues 27:73–85

    Google Scholar 

  • McCoy CB, McCoy HV, Lai S, Yu Z, Wang X, Meng J (2001) Reawakening the dragon: changing patterns of opiate use in Asia, with particular emphasis on China’s Yunnan province. Subst Use Misuse 36:49–69

    Article  CAS  PubMed  Google Scholar 

  • Michels IL, Zhao D, Fang XF, Zhao LY, Lu L (2007) Comparison of drug abuse in Germany and in China. Acta Pharmacol Sin 28:1505–1518

    Article  CAS  PubMed  Google Scholar 

  • Montazeri K, Farahnakian M, Saghaei M (2002) The effect of acupuncture on the acute withdrawal symptoms from rapid opiate detoxification. Acta Anaesthesiol Sin 40:173–177

    PubMed  Google Scholar 

  • Naik TN, Sarkar S, Singh HL, Bhunia SC, Singh YI, Singh PK, Pal SC (1991) Intravenous drug users–a new high-risk group for HIV infection in India. Aids 5:117–118

    Article  CAS  PubMed  Google Scholar 

  • National Institute on Drug Dependence and Drug Abuse Surveillance Center (2003) Report of drug surveillance 2003. National Institute on Drug Dependence and Drug Abuse Surveillance Center, Beijing

  • National Institute on Drug Dependence and National Drug Abuse Surveillance Center (2004) Report of drug surveillance 2004. Beijing: National Institute on Drug Dependence and National Drug Abuse Surveillance Center, Beijing

  • Nu WM, Liu HY, Zhang YH (2000) The application of auriculo-acupuncture on withdrawal syndrome induced by morphine. J Shanghai Acupuncture 19:18–19

    Google Scholar 

  • Ou GZ, Cui J, Zhou Y (1998) The studies of effects of acupuncture on dependent behavior induced by morphine in mice. Chinese acupuncture & moxibustion. Zhongguo Zhen Jiu 18:549–550

    Google Scholar 

  • Poroy II (1981) Expansion of opium production in Turkey and the state monopoly of 1828–1839. Int J Middle East Stud 13:191–211

    Google Scholar 

  • Qian HZ, Schumacher JE, Chen HT, Ruan YH (2006) Injection drug use and HIV/AIDS in China: Review of current situation, prevention and policy implications. Harm Reduct J 10:1183–1184

    Google Scholar 

  • Shi J, Liu YL, Fang YX, Xu GZ, Zhai HF, Lu L (2006) Traditional Chinese medicine in treatment of opiate addiction: a review. Acta Pharmacol Sin 27(10):1303–1308

    Article  PubMed  CAS  Google Scholar 

  • Shi J, Zhao LY, Epstein D, Zhao C, Shuai Y, Yan B, Jin J, Lu L. The effect of methadone maintenance on HIV and HCV infection, health status, employment, and criminal activity among heroin abusers during six months of treatment in China. J Addict Med (in press)

  • Shi J, Zhao LY, Epstein DH, Zhang XL, Lu L (2007) Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers. Pharmacol Biochem Behav 87(1):141–145

    Article  CAS  PubMed  Google Scholar 

  • Shibata S, Minamoto Y, Ono M, Watanabe S (1994) Age-related impairment of food anticipatory locomotor activity in rats. Physiol Behav 55:875–878

    Article  CAS  PubMed  Google Scholar 

  • Shwartz M, Saitz R, Mulvey K, Brannigan P (1999) The value of acupuncture detoxification programs in a substance abuse treatment system. J Subst Abuse Treat 17:305–312

    Article  CAS  PubMed  Google Scholar 

  • Simpson DD, Joe GW, Broome KM, Hiller ML, Knight K, Rowanszal GA (1997) Program diversity and treatment retention rates in the Drug Abuse Treatment Outcome Study (DATOS). Psychol Addict Behav 11:279–293

    Article  Google Scholar 

  • Sullivan SG, Wu ZY (2007) Rapid scale up of harm reduction in China. Int J Drug Policy 18(2):118–28

    Article  PubMed  Google Scholar 

  • Tang YL, Hao W (2007) Improving drug addiction treatment in China. Addiction 102(7):1057–63

    Article  PubMed  Google Scholar 

  • Tang YL, Wiste A, Mao PX, Hou YZ (2005) Attitudes, knowledge, and perceptions of Chinese doctors toward drug abuse. J Subst Abuse Treat 29:215–220

    Article  PubMed  Google Scholar 

  • Thompson D (2005) The “People’s War” against drug and HIV/AIDS. China Brief 5(14):3–4

    Google Scholar 

  • Washburn AM, Fullilove RE, Fullilove MT, Keenan PA, McGee B, Morris KA, Sorensen JL, Clark WW (1993) Acupuncture heroin detoxification: a single-blind clinical trial. J Subst Abuse Treat 10:345–351

    Article  CAS  PubMed  Google Scholar 

  • Watanabe H (1997) Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine. Behav Brain Res 83:135–141

    Article  CAS  PubMed  Google Scholar 

  • Wen L, Zheng YS, Yu LZ (1995) Effects of modified shen fu decoction on withdrawal symptoms in morphine-dependent mice and rats. Chin J Integr Tradit West Med 15:541–543

    Google Scholar 

  • Wolf ME, Sun X, Mangiavacchi S, Chao SZ (2004) Psychomotor stimulants and neuronal plasticity. Neuropharmacology 47(Suppl 1):61–79

    Article  CAS  PubMed  Google Scholar 

  • Xue LY, Wang ZC, Du YJ, Fei H (2002) Retrospective investigation of the epidemiology and characteristics of drug abuse in Shanghai. Chin J Drug Depend 11:47–50

    Google Scholar 

  • Yang H, Li X, Stanton B, Liu H, Liu H, Wang N, Fang X, Lin D, Chen X (2005) Heterosexual transmission of HIV in China: a systematic review of behavioral studies in the past two decades. Sex Transm Dis 32:270–280

    Article  PubMed  Google Scholar 

  • Yang MM, Kwok JS (1986) Evaluation on the treatment of morphine addiction by acupuncture Chinese herbs and opioid peptides. Am J Chin Med 14:46–50

    Article  CAS  PubMed  Google Scholar 

  • Yu J, Zhang X, Epstein DH, Fang Y, Shi J, Qin H, Yao S, Le Foll B, Lu L (2007) Gender and stimulus difference in cue-induced responses in abstinent heroin users. Pharmacol Biochem Behav 86(3):485–492

    Article  CAS  PubMed  Google Scholar 

  • Zhang XF, Li X, Feng CX (1998) Clinical study on electro-acupuncture treatment for protracted withdrawal syndromes of opiate dependence. Chin J Drug Depend 7:152–155

    Google Scholar 

  • Zhao C, Liu Z, Zhao D, Liu Y, Liang J, Tang Y, Liu Z, Zheng J (2004) Drug abuse in China. Ann NY Acad Sci 1025:439–445

    Article  PubMed  Google Scholar 

  • Zhuang TX, Chen XG, Jiang GH (1995) Treatment of heroin addict with acupuncture and herbal medicine: an observation of 25 cases. J Guangdong Coll Tradit Chin Med 12:33–35

    Google Scholar 

Download references

Acknowledgments

This work was supported in part by the 985 program of Peking University (No: 985-2-046-121 and 985-2-027-39), the New Century Talent Scientist Grant of Ministry of Education, the National Basic Research Program of China (No: 20003CB 515400), the 863 project of Ministry of Science and Technology of China (2006AA02Z4D1), the Natural Science Foundation of China (No: 30570576 and 30670713), and the China-Canada Joint Health Research Program (No: 30611120528). We thank Yu Liu, Liyan Zhao and Emily Wentzell for their assistance in preparing this paper.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lin Lu.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10571-009-9479-y

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, L., Fang, Y. & Wang, X. Drug Abuse in China: Past, Present and Future. Cell Mol Neurobiol 28, 479–490 (2008). https://doi.org/10.1007/s10571-007-9225-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10571-007-9225-2

Keywords

Navigation