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Cellular and Molecular Neurobiology

, Volume 26, Issue 4–6, pp 577–589 | Cite as

Implication of Cannabinoids in Neurological Diseases

  • Angela Alsasua del ValleEmail author
Article

SUMMARY

1. Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally.

2. Recent advances in the knowledge of its pharmacological and chemical properties in the organism, mainly due to Δ9-tetrahydrocannabinol, and the physiological roles played by the endocannabinoids have opened up new strategies in the treatment of neurological and psychiatric diseases.

3. Potential therapeutic uses of cannabinoid receptor agonists include the management of spasticity and tremor in multiple sclerosis/spinal cord injury, pain, inflammatory disorders, glaucoma, bronchial asthma, cancer, and vasodilation that accompanies advanced cirrhosis. CB1 receptor antagonists have therapeutic potential in Parkinson's disease.

4. Dr. Julius Axelrod also contributed in studies on the neuroprotective actions of cannabinoids.

KEY WORDS:

cannabinoids tetrahydrocannabinol epilepsy neurological diseases multiple sclerosis neuroprotective effects 

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© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Dpto. Farmacología, Facultad de MedicinaUniversidad Complutense de MadridMadridSpain

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