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Clinical Catecholamine Neurochemistry: A Legacy of Julius Axelrod

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Cellular and Molecular Neurobiology Aims and scope Submit manuscript

1. Discoveries, insights, and concepts that Julius Axelrod introduced about the disposition and metabolism of catecholamines provided the scientific basis and spurred the development of clinical catecholamine neurochemistry.

2. Here, we provide examples of this aspect of Axelrod's scientific legacy.

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Abbreviations

MAO:

monoamine oxidase

COMT:

catechol-O-methyltransferase

DBH:

dopamine-ß-hydroxylase

DHMA:

3,4-dihydroxymandelic acid

DHPG:

3,4-dihydroxyphenylglycol

DOPEGAL:

3,4-dihydroxyphenylglycolaldehyde

DOPAC:

3,4-dihydroxyphenylacetic acid

DOPET:

3,4-dihydroxyphenylethanol

DOPAL:

3,4-dihydroxyphenylacetaldehyde

EPI:

epinephrine

HVA:

homovanillic acid

LAAAD:

L-aromatic-amino-acid decarboxylase

MHPG:

3-methoxy-4-hydroxyphenylglycol

MIBG:

metaiodobenzylguanidine

MN:

metanephrine

3-MT:

3-methoxytyrosine

NE:

norepinephrine

PD:

Parkinson disease

NMN:

normetanephrine

PNMT:

phenylethanolamine-N-methyltransferase

TH:

tyrosine hydroxylase

VMA:

vanillylmandelic acid

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Authors and Affiliations

  1. Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

    David S. Goldstein, Graeme Eisenhofer & Irwin J. Kopin

  2. National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC-1620, Bethesda, MD, 20892-1620, USA

    David S. Goldstein

Authors
  1. David S. Goldstein
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  2. Graeme Eisenhofer
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  3. Irwin J. Kopin
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Correspondence to David S. Goldstein.

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Goldstein, D.S., Eisenhofer, G. & Kopin, I.J. Clinical Catecholamine Neurochemistry: A Legacy of Julius Axelrod. Cell Mol Neurobiol 26, 693–700 (2006). https://doi.org/10.1007/s10571-006-9041-0

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  • DOI: https://doi.org/10.1007/s10571-006-9041-0

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