Abstract
Ocular bacterial infection is one of the causes of tear pH decrease; nonetheless, the common topical drugs give low bioavailability. For simultaneous diagnosis and treatment, theranostic contact lens integrated with cellulose nanofibril/levofloxacin nanocomposite is developed. Cellulose nanofibrils is selected to increase surface area with hydroxyl groups for improving drug binding efficiency without significant lens surface roughness alteration, and increasing contact len hydrophilicity. The as prepared contact lens exhibits the satisfied results for both diagnosis and drug releasing. The sensing function of the lens shows sensitive responses towards tear with R2 of 0.9601, and also illustrates vivid color change when the tear pH decreases, indicating the infection severity. At healthy eye condition, the lens displays vibrant green color while turns orange-red color at infections condition. Theranostic contact lens offers pH-responsive releasing behavior with high content of levofloxacin (up to 106.49 ± 0.77 µg over 24 h) resulting from drug-CNFs interaction that releases in acid condition of infection state, yet the drug content substantially decreases when pH increases. Furthermore, the cellulose nanofibrils-based theranostic lens offers non-cytotoxicity verified by MTT. This platform might assist both ophthalmologists and patients by facilitating diagnosis and treatment without invasive procedure.
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Acknowledgments
Dr. Tatiya Siripongpreda and Dr. Nadnudda Rodthongkum would like to acknowledge The Second Century Fund (C2F), Chulalongkorn University and Dutsadi phiphat scholarship of Chulalongkorn University, Thailand. This project is funded by National Research Council of Thailand (NRCT): N41A640074.
Funding
This project is funded by The Second Century Fund (C2F) Chulalongkorn University, Dutsadi phiphat scholarship of Chulalongkorn University and National Research Council of Thailand (NRCT): N41A640074.
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Material preparation, data collection, analysis, and first draft of the manuscript were performed and written by Tatiya Siripongpreda. Conceptualization and visualization were performed by Pear Pongsachareonnont. Funding acquisition, conceptualization, supervision, validation, review and editing were performed by Nadnudda Rodthongkum.
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Siripongpreda, T., Pongsachareonnont, P., Chanajaree, R. et al. Theranostic contact lens based on cellulose nanofibrils/levofloxacin nanocomposite for ocular bacterial infection. Cellulose 30, 7141–7155 (2023). https://doi.org/10.1007/s10570-023-05327-0
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DOI: https://doi.org/10.1007/s10570-023-05327-0