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Study on the effect of tunicate cellulose nanocrystals in the preparation of sodium alginate-based enteric capsule

Abstract

In this work, tunicate cellulose nanocrystals (tCNCs) were extracted from the tunicate by bleaching and acid hydrolysis. They were used as filler in the preparation of sodium alginate-based enteric capsules. The addition of tCNCs with a high aspect ratio (65) rendered the enteric capsule excellent physical properties. Compared with the control sample, when the addition of tCNCs were 10% (wt), the water contact angle of the capsule was enhanced by 46.0%, the opacity was increased by 356.8%, the maximum tensile stress was increased by 142.6%, the modulus of elasticity was increased by 240.3%, and the elongation at break was increased by 133.8%. In the in vitro degradation experiments, the capsule hardly degraded in the gastric environment (pH 1.2), while in the intestinal environment (pH 6.8), the degradation became slower with the increase of tCNC content, which was consistent with the properties of the enteric capsule. This research developed a new direction for the application of tCNCs in the pharmaceutical material productions.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (22078061), National Key Research and Development Program of China (2017YFB0307900), the guide project from Department of Science and Technology of Fujian Province (2018H0006), and the Foundation (KF201922) of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences.

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DX: Conceptualization, methodology, validation, formal analysis, investigation. YC: Conceptualization, methodology, validation, formal analysis, investigation. SW: Resources, data curation, writing—original draft. QZ and AKM: Methodology, validation, formal analysis, investigation. DN: Writing—review and editing, visualization. FH: Supervision, writing—review and editing, project administration, funding acquisition.

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Correspondence to Fang Huang.

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Xu, D., Cheng, Y., Wu, S. et al. Study on the effect of tunicate cellulose nanocrystals in the preparation of sodium alginate-based enteric capsule. Cellulose 29, 2497–2511 (2022). https://doi.org/10.1007/s10570-022-04445-5

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  • DOI: https://doi.org/10.1007/s10570-022-04445-5

Keywords

  • Tunicate cellulose nanocrystal
  • Sodium alginate
  • Enteric-soluble
  • Capsule