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Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites

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Pectin/bacteria cellulose (BC) hydrogel composites with various BC contents have been fabricated for the purpose of electrically controlled transdermal drug delivery. A conductive polymer, polypyrrole, was successfully incorporated into the pectin/BC hydrogel composite as a host of drug encapsulation for controlled release under applied electric field. Ibuprofen as a model drug was studied for its release behavior based on the effects of matrix composition, pH stimulation, matrix mesh size, and applied electrical potential by using a modified Franz diffusion cell. The drug release was optimized at 30 wt% BC and increased with applying electrical potential. The highest amount of drug release was 78% which was obtained on a drug-loaded polypyrrole-incorporated composite under applied electrical potential at 7 V. The hydrogel composites also presented the remarkable benefit of antibacterial activity for gram-positive bacteria. Thus, the hydrogel composites are valuable alternative materials for transdermal drug delivery.

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This research was supported by King Mongkut’s University of Technology Thonburi under KMUTT Research Center of Excellence Project and Thailand Science Research and Innovation (TSRI) Basic Research Fund: Fiscal year 2021 under project number 64A306000039. NK give thanks to National Taiwan University of Science and Technology, Taiwan, for the financial support by a student scholarship. The authors would like to acknowledge Professor Paripok Phitsuwan from LigniTech-Lignin Technology Research Group, School of Bioresources and Technology, Bioresources and Technology, King Mongkut’s University of Technology Thonburi for teaching technical experiment.

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NK: Conceptualization, methodology, investigation, visualization, writing—original draft the manuscript. TI: Supervision, visualization, writing—review and editing the manuscript. NP: Supervision, conceptualization, methodology, funding acquisition, writing—review and editing draft the manuscript.

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Correspondence to Toyoko Imae or Nophawan Paradee.

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Krathumkhet, N., Imae, T. & Paradee, N. Electrically controlled transdermal ibuprofen delivery consisting of pectin-bacterial cellulose/polypyrrole hydrogel composites. Cellulose 28, 11451–11463 (2021).

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