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Biocompatible composite of cellulose nanocrystal and hydroxyapatite with large mechanical strength


Exploring the simple fabrication process to prepare CNC@HAp for biological tissues is still a challenging subject considering the wide applications of the composites for bio tissues. In this work, aiming for the fabrication of CNC@HAp composites via a simple and environment-friendly process and materials, we propose the neutralization titration in the presence of CNCs in the suspension. Core–shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via simple aqueous neutralization titration. The method studied successfully hybridizes CNCs with a certain amount of HAps and easily controls the coating amounts of HAps from 9 wt% to 17 wt%. In particular, CNC@HAp pellets were easily prepared by simple compression molding from the powder of hybridized CNCs and HAps and the pellets showed high mechanical strength of over 500 N with a low strain of less than 5%. Both the process and the product of the study were environmental-friendly, no toxicity, simple and pure therefore the CNC@HAp can be easily applied to tissue engineering and medical purposes.

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Cellulose Nanocrystal




Composite of cellulose and hydroxyapatite


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This work was supported by the cooperative research program of “Network Joint Research Center for Materials and Devices” and JSPS KAKENHI No. JP18H01717.

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Correspondence to Toshihiko Arita or Akito Masuhara.

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Sato, R., Arita, T., Shimada, R. et al. Biocompatible composite of cellulose nanocrystal and hydroxyapatite with large mechanical strength. Cellulose 28, 871–879 (2021).

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  • Cellulose nanocrystal
  • Hydroxyapatite
  • Biomedical materials
  • Tissue engineering materials
  • Dental materials
  • Sustainable development goals (SDGs)