Abstract
Temperature-responsive aerogels from hydroxypropyl methylcellulose (HPMC)-grafted N-isopropylacrylamide (NIPAM) were developed for the first time as a novel drug delivery system. The morphology and structure of temperature-responsive HPMC-NIPAM aerogels were characterized with scanning electron microscopy, Fourier-transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopic analyses. Water-soluble 5-fluorouracil was used as a model drug to study drug loading and release. Drug release experiments demonstrated a sustained and controlled release behavior of the HPMC-NIPAM aerogels that were highly dependent on temperature. Meanwhile, the first-order kinetic model, Higuchi model, and Korsmyer–Peppas model were used to fit the sustained-release curve of drug-loaded aerogel revealing a sustained-release mechanism.
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Acknowledgments
The authors are grateful for the National Natural Science Foundation of China (Grant Nos. 31971605), International Joint Research Center for biomass chemistry and materials, Shaanxi international science and technology cooperation base (2018GHJD-19), the Shandong Key R&D Program (No. 2019JZZY010407 and 2019JZZY010304), Key scientific research plan (Key Laboratory) of Shaanxi Provincial Education Department (No.17JS016). The Project also was supported by the Foundation (No. KF201814) of Key Laboratory of Pulp and Paper Science and Technology of Ministry of Education/Shandong Province of China. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.
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Liu, Z., Zhang, S., He, B. et al. Temperature-responsive hydroxypropyl methylcellulose-N-isopropylacrylamide aerogels for drug delivery systems. Cellulose 27, 9493–9504 (2020). https://doi.org/10.1007/s10570-020-03426-w
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DOI: https://doi.org/10.1007/s10570-020-03426-w