Skip to main content
Log in

Eco-friendly technology for preparation, characterization and promotion of honey bee propolis extract loaded cellulose acetate nanofibers in medical domains

  • Original Paper
  • Published:
Cellulose Aims and scope Submit manuscript

A Correction to this article was published on 16 September 2022

This article has been updated

Abstract

Honey bee propolis extract (HBP) was prepared by three methods; namely, soxhlet-reflux, magnetic stirring and ultrasound extraction. Based on the efficacies of HBP formation, the soxhlet-reflux method gave the highest yield of HBP. Electrospinning of cellulose acetate (CA) solution loaded with different concentrations of HBP was assessed. The results show that the surface morphology of CA nanofibers characterized by SEM changes with the addition of HBP to CA solution. The thermal stability of the as-formed CA/HBP marginally increases when compared with CA nanofibers. It was also observed that the CA/HBP nanofibers are effective inhibitors of growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Additionally, the in vitro release results of HBP from CA nanofibers displayed that the HBP release is sustained and controlled in neutral pH rather than alkaline and acid pH.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Change history

References

  • Abdelgawad AM, El-Naggar ME, Hudson SM, Rojas OJ (2017) Fabrication and characterization of bactericidal thiol-chitosan and chitosan iodoacetamide nanofibres. Int J Biol Macromol 94:96–105

    Article  CAS  Google Scholar 

  • Bhardwaj N, Kundu SC (2010) Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 28:325–347

    Article  CAS  Google Scholar 

  • Castillo-Ortega M, Nájera-Luna A, Rodríguez-Félix D, Encinas J, Rodríguez-Félix F, Romero J, Herrera-Franco P (2011) Preparation, characterization and release of amoxicillin from cellulose acetate and poly (vinyl pyrrolidone) coaxial electrospun fibrous membranes. Mater Sci Eng C 31:1772–1778

    Article  CAS  Google Scholar 

  • Chan GCF, Cheung KW, Sze DMY (2013) The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 44:262–273

    Article  CAS  Google Scholar 

  • Chen J-Y, Chen H-C, Lin J-N, Kuo C (2008) Effects of polymer media on electrospun mesoporous titania nanofibers. Mater Chem Phys 107:480–487

    Article  CAS  Google Scholar 

  • de Lima GG, de Souza RO, Bozzi AD, Poplawska MA, Devine DM, Nugent MJ (2016) Extraction method plays critical role in antibacterial activity of propolis-loaded hydrogels. J Pharm Sci 105:1248–1257

    Article  Google Scholar 

  • El-Feky GS, Sharaf SS, El Shafei A, Hegazy AA (2017) Using chitosan nanoparticles as drug carriers for the development of a silver sulfadiazine wound dressing. Carbohydr Polym 158:11–19

    Article  CAS  Google Scholar 

  • El-Naggar ME, Abdelgawad AM, Salas C, Rojas OJ (2016) Curdlan in fibers as carriers of tetracycline hydrochloride: controlled release and antibacterial activity. Carbohydr Polym 154:194–203

    Article  CAS  Google Scholar 

  • El-Newehy MH, El-Naggar ME, Alotaiby S, El-Hamshary H, Moydeen M, Al-Deyab S (2016) Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium. J Macromol Sci Part A 53:566–573

    Article  CAS  Google Scholar 

  • El-Newehy MH, El-Naggar ME, Alotaiby S, El-Hamshary H, Moydeen M, Al-Deyab S (2018) Green electrospining of hydroxypropyl cellulose nanofibres for drug delivery applications. J Nanosci Nanotechnol 18:805–814

    Article  CAS  Google Scholar 

  • Fathi-Azarbayjani A, Qun L, Chan YW, Chan SY (2010) Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. AAPS Pharmscitech 11:1164–1170

    Article  CAS  Google Scholar 

  • Ghisalberti E (1979) Propolis: a review. Bee world 60:59–84

    Article  CAS  Google Scholar 

  • Hebeish A, El-Rafie M, Rabie A, El-Sheikh M, El-Naggar ME (2014) Ultra-microstructural features of perborate oxidized starch. J Appl Polym Sci 131:40170–40179

    Article  Google Scholar 

  • Kim JI, Pant HR, Sim H-J, Lee KM, Kim CS (2014) Electrospun propolis/polyurethane composite nanofibers for biomedical applications. Mater Sci Eng C 44:52–57

    Article  Google Scholar 

  • Lagouri V, Prasianaki D, Krysta F (2014) Antioxidant properties and phenolic composition of Greek propolis extracts. Int J Food Prop 17:511–522

    Article  CAS  Google Scholar 

  • Li H, Xu Y, Xu H, Chang J (2014a) Electrospun membranes: control of the structure and structure related applications in tissue regeneration and drug delivery. J Mater Chem B 2:5492–5510

    Article  CAS  Google Scholar 

  • Li R, Dou J, Jiang Q, Li J, Xie Z, Liang J, Ren X (2014b) Preparation and antimicrobial activity of β-cyclodextrin derivative copolymers/cellulose acetate nanofibers. Chem Eng J 248:264–272

    Article  CAS  Google Scholar 

  • Liu Y, Nguyen A, Allen A, Zoldan J, Huang Y, Chen JY (2017) Regenerated cellulose micro-nano fiber matrices for transdermal drug release. Mater Sci Eng C 74:485–492

    Article  CAS  Google Scholar 

  • Matei PM et al. (2015) Synthesis of chitosan oligomers/propolis/silver nanoparticles composite systems and study of their activity against Diplodia seriata. Int J Polym Sci 2015:1–11

    Article  Google Scholar 

  • Meng C et al (2015) Activation of cellulose by supercritical tetrafluoroethane and its application in synthesis of cellulose acetate. Ind Eng Chem Res 54:12204–12213

    Article  CAS  Google Scholar 

  • Popova M, Silici S, Kaftanoglu O, Bankova V (2005) Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition. Phytomedicine 12:221–228

    Article  CAS  Google Scholar 

  • Rogina A (2014) Electrospinning process: versatile preparation method for biodegradable and natural polymers and biocomposite systems applied in tissue engineering and drug delivery. Appl Surf Sci 296:221–230

    Article  CAS  Google Scholar 

  • Schreuder-Gibson HL, Truong Q, Walker JE, Owens JR, Wander JD, Jones WE (2003) Chemical and biological protection and detection in fabrics for protective clothing. MRS Bull 28:574–578

    Article  CAS  Google Scholar 

  • Sharaf S, Higazy A, Hebeish A (2013) Propolis induced antibacterial activity and other technical properties of cotton textiles. Int J Biol Macromol 59:408–416

    Article  CAS  Google Scholar 

  • Wang J, Windbergs M (2017) Functional electrospun fibers for the treatment of human skin wounds. Eur J Pharm Biopharm 119:283–299

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This project was supported financially by the Science and Technology Development Fund (STDF), Egypt, RSTDG, Grant number 14918.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mehrez E. El-Naggar.

Additional information

The original online version of this article was revised: Figure 3 is updated.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 234 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharaf, S., El-Naggar, M.E. Eco-friendly technology for preparation, characterization and promotion of honey bee propolis extract loaded cellulose acetate nanofibers in medical domains. Cellulose 25, 5195–5204 (2018). https://doi.org/10.1007/s10570-018-1921-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10570-018-1921-1

Keywords

Navigation