, Volume 22, Issue 2, pp 1389–1400 | Cite as

Cellulose acetate core–shell structured electrospun fiber: fabrication and characterization

  • Abdurizzagh Khalf
  • Kumar Singarapu
  • Sundararajan V. Madihally
Original Paper


This study explored the effect of type of core fluids on the fabrication of hollow and core–sheath cellulose acetate (CA) fiber. Tailoring the CA fiber with desirable features such as reinforced core, porous and hollow structure provides unique features for use in various applications. Fibers with such characteristics can be used for better controlled release drug delivery system or to promote cell adhesion in tissue engineering. Type of core material, tensile strength, and rheological properties were evaluated. DSC and FTIR analysis were performed to confirm the presence of core and sheath components. CA hollow structures were successfully obtained after selectively extracting the mineral oil. CA hollow fibers were twice the size of solid fiber despite similar solution and process conditions. Fiber morphologies indicated incomplete encapsulation by the CA when 80 kDa PCL molecular weight was used. This problem was not observed with 43 and 10 kDa PCL. DSC and FTIR analyses showed presence of both PCL and CA components. The rheology results suggest that the fibers could be formed when the viscosity of the core is less than that of sheath. Hydrated CA–43 kDa PCL fibers showed nearly ten-fold improvement in break point and stiffness. Human umbilical vein endothelial cells showed increased attachment and viability in both hollow CA and CA–PCL fibers relative to tissue culture plastic.


Polymers Mechanical properties Electrospinning Scanning electron microscopy Rheology 



Financial support was provided by the Oklahoma Center for Advancement of Science and Technology (HR12-023) and Edward Joullian Endowment.


  1. Du J, Hsieh YL (2009) Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives. Cellulose 16(2):247–260CrossRefGoogle Scholar
  2. Gouda M, Hebeish AA, Al-Omair MA (2014) Development of silver-containing nanocellulosics for effective water disinfection. Cellulose 21(3):1965–1974CrossRefGoogle Scholar
  3. Hong JK, Madihally SV (2010) Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration. Acta Biomater 6(12):4734–4742CrossRefGoogle Scholar
  4. Hong JK, Madihally SV (2011) Next generation of electrosprayed fibers for tissue regeneration. Tissue Eng Part B Rev 17(2):125–142CrossRefGoogle Scholar
  5. Hong JK, Xu G, Piao DQ, Madihally SV (2013) Analysis of void shape and size in the collector plate and polycaprolactone molecular weight on electrospun scaffold pore size. J Appl Polym Sci 128(3):1583–1591Google Scholar
  6. Iyer P, Walker KJ, Madihally SV (2012) Increased matrix synthesis by fibroblasts with decreased proliferation on synthetic chitosan–gelatin porous structures. Biotechnol Bioeng 109(5):1314–1325CrossRefGoogle Scholar
  7. Kamide K, Saito M (1985) Thermal-analysis of cellulose-acetate solids with total degrees of substitution of 0.49, 1.75, 2.46, and 2.92. Polym J 17(8):919–928CrossRefGoogle Scholar
  8. Lee YS, Arinzeh TL (2011) Electrospun nanofibrous materials for neural tissue engineering. Polymers 3(1):413–426CrossRefGoogle Scholar
  9. Li J, He A, Aheng J, Han CC (2006) Gelatin and gelatin hyaluronic acid nanofibrous membranes produced by electrospinning of their aqueous solutions. Biomacromolecules 7:2243–2247CrossRefGoogle Scholar
  10. Liu HQ, Hsieh YL (2002) Ultrafine fibrous cellulose membranes from electrospinning of cellulose acetate. J Polym Sci Part B Polym Phys 40(18):2119–2129CrossRefGoogle Scholar
  11. Liu X, Smith LA, Hu J, Ma PX (2009) Biomimetic nanofibrous gelatin/apatite compsite scaffolds for bone tissue engineering. Biomaterials 30:2252–2258CrossRefGoogle Scholar
  12. Lu Y, Jiang H, Tu K, Wang L (2009) Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning. Acta Biomater 5(5):1562–1574CrossRefGoogle Scholar
  13. Md. Fazley Elahi WL, Guoping G, Khan F (2013) Core–shell fibers for biomedical applications–a review. Bioeng Biomed Sci 3(1):2155–9538Google Scholar
  14. Mirani RD, Pratt J, Iyer P, Madihally SV (2009) The stress relaxation characteristics of composite matrices etched to produce nanoscale surface features. Biomaterials 30(5):703–710CrossRefGoogle Scholar
  15. Oh SH, Park IK, Kim JM, Lee JH (2007) In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 28(9):1664–1671CrossRefGoogle Scholar
  16. Qu HL, Wei SY, Guo ZH (2013) Coaxial electrospun nanostructures and their applications. J Mater Chem A 1(38):11513–11528CrossRefGoogle Scholar
  17. Rada T, Reis RL, Gomes ME (2009) Adipose tissue-derived stem cells and their application in bone and cartilage tissue engineering. Tissue Eng Part B Rev 15(2):113–125CrossRefGoogle Scholar
  18. Rodriguez K, Gatenholm P, Renneckar S (2012) Electrospinning cellulosic nanofibers for biomedical applications: structure and in vitro biocompatibility. Cellulose 19(5):1583–1598CrossRefGoogle Scholar
  19. Salihu G, Goswami P, Russell S (2012) Hybrid electrospun nonwovens from chitosan/cellulose acetate. Cellulose 19(3):739–749CrossRefGoogle Scholar
  20. Saraf A, Baggett LS, Raphael RM, Kasper FK, Mikos AG (2010) Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds. J Control Release 143(1):95–103CrossRefGoogle Scholar
  21. Sarasam A, Madihally SV (2005) Characterization of chitosan–polycaprolactone blends for tissue engineering applications. Biomaterials 26(27):5500–5508CrossRefGoogle Scholar
  22. Seal BL, Otero TC, Panitch A (2001) Polymeric biomaterials for tissue and organ regeneration. Mater Sci Eng R Rep 34(4–5):147–230CrossRefGoogle Scholar
  23. Sethuraman V, Makornkaewkeyoon K, Khalf A, Madihally SV (2013) Influence of scaffold forming techniques on stress relaxation behavior of polycaprolactone scaffolds. J Appl Polym Sci 130(6):4237–4244Google Scholar
  24. Son WK, Youk JH, Lee TS, Park WH (2004) Electrospinning of ultrafine cellulose acetate fibers: studies of a new solvent system and deacetylation of ultrafine cellulose acetate fibers. J Polym Sci Part B Polym Phys 42(1):5–11CrossRefGoogle Scholar
  25. Sousa M, Bras AR, Veiga HIM, Ferreira FC, de Pinho MN, Correia NT, Dionisio M (2010) Dynamical characterization of a cellulose acetate polysaccharide. J Phys Chem B 114(34):10939–10953CrossRefGoogle Scholar
  26. Tiwari SK, Tzezana R, Zussman E, Venkatraman SS (2010) Optimizing partition-controlled drug release from electrospun core–shell fibers. Int J Pharm 392(1–2):209–217CrossRefGoogle Scholar
  27. Tungprapa S, Puangparn T, Weerasombut M, Jangchud I, Fakum P, Semongkhol S, Meechaisue C, Supaphol P (2007) Electrospun cellulose acetate fibers: effect of solvent system on morphology and fiber diameter. Cellulose 14(6):563–575CrossRefGoogle Scholar
  28. Vince Beachley XW (2009) Effect of electrospinning parameters on the nanofiber diameter and length. Mater Sci Eng 29:663–668CrossRefGoogle Scholar
  29. Wang C, Yan K-W, Lin Y-D, Hsieh PCH (2010) Biodegradable core/shell fibers by coaxial electrospinning: processing, fiber characterization, and its application in sustained drug release. Macromolecules 43(15):6389–6397CrossRefGoogle Scholar
  30. Wei M, Kang BW, Sung CM, Mead J (2006) Core–sheath structure in electrospun nanofibers from polymer blends. Macromol Mater Eng 291(11):1307–1314CrossRefGoogle Scholar
  31. Woodruff MA, Hutmacher DW (2010) The return of a forgotten polymer—polycaprolactone in the 21st century. Prog Polym Sci 35(10):1217–1256CrossRefGoogle Scholar
  32. Xie JW, Willerth SM, Li XR, Macewan MR, Rader A, Sakiyama-Elbert SE, Xia YN (2009) The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 30(3):354–362CrossRefGoogle Scholar
  33. Yu DG, Yu JH, Chen L, Williams GR, Wang X (2012) Modified coaxial electrospinning for the preparation of high-quality ketoprofen-loaded cellulose acetate nanofibers. Carbohydr Polym 90(2):1016–1023CrossRefGoogle Scholar
  34. Yu DG, Li XY, Wang X, Chian W, Liao YZ, Li Y (2013) Zero-order drug release cellulose acetate nanofibers prepared using coaxial electrospinning. Cellulose 20(1):379–389CrossRefGoogle Scholar
  35. Zhang Y, Ouyang H, Lim CT, Ramakrishna S, Huang ZM (2005) Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scafolds. J Biomed Mater Res B Appl Biomater 72:156–165CrossRefGoogle Scholar
  36. Zhang ZP, Hu J, Ma PX (2012) Nanofiber-based delivery of bioactive agents and stem cells to bone sites. Adv Drug Deliv Rev 64(12):1129–1141CrossRefGoogle Scholar
  37. Zonari A, Novikoff S, Electo NRP, Breyner NM, Gomes DA, Martins A, Neves NM, Reis RL, Goes AM (2012) Endothelial differentiation of human stem cells seeded onto electrospun polyhydroxybutyrate/polyhydroxybutyrate-co-hydroxyvalerate fiber mesh. PLoS One 7(4):e35422. doi: 10.1371/journal.pone.0035422

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Abdurizzagh Khalf
    • 1
  • Kumar Singarapu
    • 1
  • Sundararajan V. Madihally
    • 1
  1. 1.School of Chemical EngineeringOklahoma State UniversityStillwaterUSA

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