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Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

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Abstract

In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV–Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.

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Acknowledgments

The paper was co-produced within the framework of the operation entitled “Centre of Open innovation and ResEarch UM (CORE@UM)”. The operation is co-funded by the European Regional Development Fund and conducted within the framework of the Operational Programme for Strengthening Regional Development Potentials for the period 2007–2013, development priority 1: “Competitiveness of companies and research excellence”, priority axis 1.1: “Encouraging competitive potential of enterprises and research excellence”, contact No. 3330-13-500032. The authors acknowledge the financial support from the Ministry of Higher Education, Science and Technology of the Republic of Slovenia and thank the Christian Doppler research association and the Austrian Ministry of Economics, Family and Youth (BMWFJ) for financial support.

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Authors and Affiliations

  1. Laboratory for Characterisation and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, 2000, Maribor, Slovenia

    Tina Maver, Stefan Spirk & Karin Stana-Kleinschek

  2. Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia

    Uroš Maver

  3. Christian Doppler Laboratory for Functional and Polymer Based Ink-Jet Inks and Chair of Chemistry of Polymeric Materials, University of Leoben, Otto-Glöckel-Strasse 2, 8700, Leoben, Austria

    Florian Mostegel & Thomas Griesser

  4. Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, 8010, Graz, Austria

    Stefan Spirk

  5. University Medical Centre Ljubljana, Zaloška cesta 2, 1000, Ljubljana, Slovenia

    Dragica Maja Smrke

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  1. Tina Maver
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  2. Uroš Maver
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  3. Florian Mostegel
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  6. Dragica Maja Smrke
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  7. Karin Stana-Kleinschek
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Correspondence to Uroš Maver or Stefan Spirk.

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All the authors have contributed to the work equally.

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Maver, T., Maver, U., Mostegel, F. et al. Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. Cellulose 22, 749–761 (2015). https://doi.org/10.1007/s10570-014-0515-9

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  • DOI: https://doi.org/10.1007/s10570-014-0515-9

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