Abstract
Cellulose beads were prepared from water-based solvent and oxidised by modified Anelli’s reaction at 20–\(80\,^\circ \hbox {C}\) for 2–48 h (Fig. 1). The maximum amount of anionic groups (AGs) was \(1.85\,\hbox {mmol}\,\hbox {g}^{-1}\). The distribution of AGs was verified by absorption of cationic dyes and imaging with confocal fluorescent microscopy. Structural changes were studied spectroscopically and with electron microscopy. Oxidation of the beads drastically increased the swelling capacity of air-dried beads. Uptake of model drug was more than doubled in never-dried beads. This is due to the changes in pore size distribution, mainly opening and widening of the closed pores and narrow cavities. Release profiles of the drug were studied at physiological pH of 7.4 and showed a controlled release rate independently of the amount of the drug encapsulated and amount of AGs.
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Acknowledgments
This work is part of Future Biorefine (FuBio) Cellulose, funded by TEKES and coordinated by Finnish Bioeconomy Cluster (FiBiC). We would also like to acknowledge the department of biology in Åbo Akademi for the fluorescent microscopy measurements.
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Trygg, J., Yildir, E., Kolakovic, R. et al. Anionic cellulose beads for drug encapsulation and release. Cellulose 21, 1945–1955 (2014). https://doi.org/10.1007/s10570-014-0253-z
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DOI: https://doi.org/10.1007/s10570-014-0253-z