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Radiation grafting of glycidyl methacrylate onto cotton gauzes for functionalization with cyclodextrins and elution of antimicrobial agents

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Abstract

The aim of this work was to functionalize cotton gauzes with cyclodextrins in order to endow them with the ability to elute antimicrobial agents and to prevent infections. Gauzes were modified according to a two-steps approach: (1) pre-irradiation of the gauzes (Gammabeam) to graft glycidyl methacrylate (GMA), and (2) covalent binding of cyclodextrins (CDs) to the GMA-grafted gauzes. First the dependence of GMA grafting yield on the radiation dose (from 1 to 20 kGy) and the time of reaction was evaluated in detail. Anchorage of β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was confirmed by FTIR, TGA, and 3-methylbenzoic acid sorption. Differently from pristine gauzes, CD-functionalized GMA-grafted gauzes were able to load an anionic antibiotic drug, specifically nalidixic acid, and to sustain the release for 6 h. Drug-loaded gauzes were tested in vitro against E. coli and the results prove the suitability of the functionalization approach to efficiently inhibit the growth of this microorganism.

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Acknowledgments

This work was supported by MICINN (SAF2011-22771), Xunta de Galicia (10CSA203013PR) and FEDER (Spain), and DGAPA-UNAM Grant IN202311 and CONACYT Project 174378 (Mexico). The authors thank to F. García and B. Leal from ICN-UNAM for technical assistance, and to B. Magariños of USC for the help with the microbiological tests. Authors also thank “Red iberoamericana de nuevos materiales para el diseño de sistemas avanzados de liberación de fármacos en enfermedades de alto impacto socioeconómico” (RIMADEL) of the Ibero-American Programme for Science, Technology and Development (CYTED).

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Authors and Affiliations

  1. Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510, Mexico, DF, Mexico

    Erick Hiriart-Ramírez & Emilio Bucio

  2. Department of Engineering Physics, École Polytechnique, C.P. 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada

    Angel Contreras-García

  3. Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain

    Maria José Garcia-Fernandez, Angel Concheiro & Carmen Alvarez-Lorenzo

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  1. Erick Hiriart-Ramírez
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  2. Angel Contreras-García
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  3. Maria José Garcia-Fernandez
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  4. Angel Concheiro
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  5. Carmen Alvarez-Lorenzo
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  6. Emilio Bucio
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Correspondence to Carmen Alvarez-Lorenzo.

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Hiriart-Ramírez, E., Contreras-García, A., Garcia-Fernandez, M.J. et al. Radiation grafting of glycidyl methacrylate onto cotton gauzes for functionalization with cyclodextrins and elution of antimicrobial agents. Cellulose 19, 2165–2177 (2012). https://doi.org/10.1007/s10570-012-9782-5

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