Cell Biology and Toxicology

, Volume 23, Issue 6, pp 373–383

Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver

Original Article

DOI: 10.1007/s10565-007-9000-7

Cite this article as:
Kaviarasan, S., Viswanathan, P. & Anuradha, C.V. Cell Biol Toxicol (2007) 23: 373. doi:10.1007/s10565-007-9000-7


Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.


Collagen Ethanol Fenugreek seeds Lipids Polyphenols 



Duncan’s multiple range test


free fatty acids


fenugreek seed polyphenol extract


hematoxylin and eosin


high-density lipoprotein cholesterol


low-density lipoprotein cholesterol






very low-density lipoprotein cholesterol

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • S. Kaviarasan
    • 1
  • P. Viswanathan
    • 2
  • C. V. Anuradha
    • 1
  1. 1.Department of Biochemistry, Faculty of ScienceAnnamalai UniversityAnnamalai NagarIndia
  2. 2.Department of Pathology, Faculty of Medicine, RMMC&HAnnamalai UniversityAnnamalai NagarIndia

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