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Photocatalysed Synthesis and Structure Activity Evaluation of Cyclohexyloxyphenethylpyridinones as Potent HIV-1 Inhibitor

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Abstract

A visible light promoted, photoredox catalysed, green one-pot approach for the synthesis of cyclohexyloxyphenethylpyridinoneshas been developed. New synthetic approach for the preparation of tailor-made synthesis of cyclohexyloxyphenethylpyridinones compounds are in extremely high demand as they display significant potent activity against wild­type HIV­1 strains as well as on mutant strains. Herein, we have designed an efficient photo-induced synthetic strategy to obtain the target compound with higher yield.

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Acknowledgements

The authors are grateful for financial support provided by University Grants Commission India (UGC start-up Project No. F.30-461/2019, BSR).

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Authors and Affiliations

  1. Department of Chemistry, CMP Degree College, University of Allahabad, Prayagraj, 211002, India

    Vishal Srivastava, Shraddha Tivari & Pravin K. Singh

  2. Department of Chemistry, United College of Engineering & Research, Naini, Prayagraj, 211010, India

    Praveen P. Singh

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  1. Vishal Srivastava
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Srivastava, V., Tivari, S., Singh, P.K. et al. Photocatalysed Synthesis and Structure Activity Evaluation of Cyclohexyloxyphenethylpyridinones as Potent HIV-1 Inhibitor. Catal Lett 154, 771–779 (2024). https://doi.org/10.1007/s10562-023-04345-8

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