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Photocatalytic One-Pot Synthesis of Quinazolinone Under Ambient Conditions

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Abstract

A novel photocatalytic cyclization reaction was developed for the synthesis of quinazolinones from o-aminobenzamides and in-situ generated aldehydes from alcohols using 9-fluorenone as the photocatalyst through a "one-pot" process. Furthermore, alcohols are perfect alternatives to aldehydes due to some unique advantages, such as being green, less toxic, available, and economical. The present protocol showed good tolerance for various substrates and could afford a range of quinazolinones (29 examples) up to 91% under ambient conditions.

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Acknowledgements

We are grateful for the financial support from the National Natural Science Foundation of China (22005179), and Natural Science Foundation of Shandong Province (ZR2020QB113, ZR2020MB018 and, ZR2021QB049).

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Authors and Affiliations

  1. School of Chemistry & Chemical Engineering, Shandong University of Technology, Zibo, 255049, Shandong, People’s Republic of China

    Mingchun Wang, Jiyuan Ren, Qi Xiao, Ao Song, Shengsheng Yu, Rongzhou Wang & Lingbao Xing

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  1. Mingchun Wang
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  2. Jiyuan Ren
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  3. Qi Xiao
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Correspondence to Rongzhou Wang or Lingbao Xing.

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Wang, M., Ren, J., Xiao, Q. et al. Photocatalytic One-Pot Synthesis of Quinazolinone Under Ambient Conditions. Catal Lett 153, 3771–3782 (2023). https://doi.org/10.1007/s10562-022-04266-y

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