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Knoevenagel Condensation of Aldehydes and Ketones with Malononitrile Catalyzed by Amine Compounds-Tethered Fe3O4@SiO2 Nanoparticles

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Abstract

A new magnetic nanoparticle supported-catalyst was developed for the Knoevenagel condensation between malononitrile and several aldehydes. The Fe3O4@SiO2-3N (where 3N = N1-(3-trimethoxysilylpropyl)diethylenetriamine) catalyst was characterized by XRD, infrared spectroscopy, and thermogravimetric analysis. The reactions provide excellent yields in a shorter reaction time in relation to others reported in the literature. The catalyst was easily recovered and reused until six times without significant loss of its catalytic capacity.

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Acknowledgements

Capes, and CNPq for the financial support and Unical (Unidade da Central Analítica) of the IPeFarM-UFPB (Instituto de Pesquisa em Fármacos e Medicamentos da UFPB) for the assistance in the NMR analysis.

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Correspondence to Juliana A. Vale.

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de Resende Filho, J.B.M., Pires, G.P., de Oliveira Ferreira, J.M.G. et al. Knoevenagel Condensation of Aldehydes and Ketones with Malononitrile Catalyzed by Amine Compounds-Tethered Fe3O4@SiO2 Nanoparticles. Catal Lett 147, 167–180 (2017). https://doi.org/10.1007/s10562-016-1916-1

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