Catalysis Letters

, Volume 146, Issue 8, pp 1341–1347 | Cite as

NiO Nanoparticles: Efficient Catalyst for Four Component Coupling Reaction for Synthesis of Substituted Pyrroles

Article

Abstract

The present protocol demonstrates the four component, coupling reactions of 1,3-dicarbonyl compounds, amines, aldehydes, and nitroalkanes for the synthesis of highly functionalized pyrroles using NiO NPs as a heterogeneous and robust catalyst. The developed protocol is simple, convenient, solvent free, straightforward, easy separation of catalyst and carried at room temperature. This methodology provides an alternative approach for easy access of highly substituted pyrroles in moderate to very good yields using four simple and readily available building blocks via one-pot tandem reaction with catalyst recyclability.

Graphical Abstract

Keywords

NiO NPs Multicomponent Solvent free Coupling reaction 

Notes

Acknowledgments

Author Aravind L. Gajengi thankful to the University Grand Commission–Basic Research Program (UGC-BSR) for providing fellowship. We are also thankful to Department of Science and Technology (DST), India for financial support under DST-Nano Mission Project No. SR/NM/NS-1097/2011.

Supplementary material

10562_2016_1762_MOESM1_ESM.docx (2.2 mb)
Supplementary material 1 (DOCX 2287 kb)

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of ChemistryInstitute of Chemical TechnologyMumbaiIndia

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