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One-pot Synthesis of 2,4,5-trisubstituted Imidazoles Catalyzed by Lipase

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Abstract

A simple and efficient protocol of synthesizing 2,4,5-trisubstituted imidazoles has been developed using lipase as a novel catalyst under mild conditions. A series of imidazole derivatives were synthesized with good yields. The probable enzymatic mechanism was proposed. This method expands the catalytic scope of lipase and provides a novel method to prepare imidazole derivatives.

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Acknowledgments

We are grateful to the National Natural Science Foundation of China (No. 21106026), Zhejiang Provincial Natural Science Foundation of China (No. Y4090052) and Key Sci-tech Innovation Team of Zhejiang Province (No. 2010R50017-7) for providing financial support.

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Authors and Affiliations

  1. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, People’s Republic of China

    Hui Zheng, Qiao Yue Shi, Kui Du, Yi Jia Mei & Peng Fei Zhang

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  1. Hui Zheng
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  2. Qiao Yue Shi
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  3. Kui Du
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  4. Yi Jia Mei
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  5. Peng Fei Zhang
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Correspondence to Hui Zheng.

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Zheng, H., Shi, Q.Y., Du, K. et al. One-pot Synthesis of 2,4,5-trisubstituted Imidazoles Catalyzed by Lipase. Catal Lett 143, 118–121 (2013). https://doi.org/10.1007/s10562-012-0920-3

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  • DOI: https://doi.org/10.1007/s10562-012-0920-3

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