Skip to main content
SpringerLink
Log in

Reductively Induced Catalytic DNA Cleavage of Water Soluble RhIII-Br8TMPyP

  • Published:
Catalysis Letters Aims and scope Submit manuscript

Abstract

The RhIII(Br8TMPyP)5+ showed a catalytic DNA cleavage in the presence of ascorbic acid. The UV–visible, Cyclic Votlammetric (CV) and Electron Spin Resonance (ESR) data confirmed involvement of the reduced form of the RhIII-Br8TMPyP, RhIII(Br8TMPyP)4+·radical, in the catalytic cycle. Gel-electrophoresis, results revealed that, RhIII(Br8TMPyP)5+ could cleave DNA at 0.01–0.1 μM levels which is significantly higher than that of other metalloporphyrins.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Scheme 1

Similar content being viewed by others

References

  1. McMillin DR, Shelton AH, Bejune SA, Fanwick PE, Wall RK (2005) Coord Chem Rev 249:1451

    Article  CAS  Google Scholar 

  2. Bernard M, Robert A, Pratviel J, Genevieve P, Bernadou P (2000) Porphyrin handbook, vol 4. Academic press, San Diego, p 119

    Google Scholar 

  3. Sashikumar M, Munson BR, Pandey RK (1999) Bioconjugate Chem 10:94

    Article  Google Scholar 

  4. Ikami-Terao MY, Akiyama M, Yuza Y, Yanagisawa T, Yamada O, Yamada H (2008) Cancer Lett 261:226

    Article  Google Scholar 

  5. Haeubl M, Schuerz S, Svejda B, Reith LM, Gruber B, Pfragner R, Schoefberger W (2010) Eur J Med Chem 45:760

    Article  CAS  Google Scholar 

  6. Nyarko E, Hanada N, Habib A, Tabata M (2004) Inorg Chim Acta 357(3):739

    Article  CAS  Google Scholar 

  7. Tabata M, Kumar SA, Nyarko E (2003) J Inorg Biochem 94(1–2):50

    Article  CAS  Google Scholar 

  8. Habib A, Tabata M (2004) J Inorg Biochem 98(11):1696

    Article  CAS  Google Scholar 

  9. Tabata M, Sarker AK, Watanabe K (1998) Chem Lett 27:325

    Article  Google Scholar 

  10. Nyarko E, Tabata M (2001) J Porp Phat 5(12):873

    Article  CAS  Google Scholar 

  11. Yamasaki S, Yamada Y, Takeda S, Goto M, Ioroi T, Siroma Z, Yasuda K (2010) Phys Chem Chem Phys 12(31):8968

    Article  Google Scholar 

  12. Del Rossi KJ, Wayland BB (1985) J Am Chem Soc 107:7941

    Article  CAS  Google Scholar 

  13. Wayland BB, Ba S, Sherry AE (1991) J Am Chem Soc 113:5305

    Article  CAS  Google Scholar 

  14. Zhang XX, Parks GF, Wayland BB (1997) J Am Chem Soc 119:7938

    Article  CAS  Google Scholar 

  15. Zhang XX, Wayland BB (1994) J Am Chem Soc 116:7879

    Google Scholar 

  16. Wayland BB, Sherry AE, Bunn AG (1993) J Am Chem Soc 115:7675

    Article  CAS  Google Scholar 

  17. Richards RA, Hammons K, Joe M, Miskelly GM (1996) Inorg Chem 35:1940

    Article  CAS  Google Scholar 

  18. Kadish KM, Yao CL, Anderson JE (1986) Inorg Chem 25:718

    Article  Google Scholar 

  19. Kadish KM, Hu Y, Boschi T, Tagliatesta P (1993) Inorg Chem 32:2296

    Google Scholar 

  20. Kadish KM, Yao CL, Anderson JE (1985) Inorg Chem 24:4515

    Article  CAS  Google Scholar 

  21. Souza F. D`, Kadish, K. M. (2006) In: Zagal JH, Bedioui F, Pol-Dodelet J (ed), N4–Macrocyclic metal complexes, (Chap. 9), Springer, New York

  22. Wayland BB, Sherry AE, Poszmik G, Bunn AG (1992) J Am Chem Soc 114:1673

    Article  CAS  Google Scholar 

  23. Field RJ, Beerman TA, Mark EH, Datta-Gupta N (1982) Biochem Biophys Res Commun 107:1067

    Article  Google Scholar 

  24. Gunawardhana N, Tabata M (2010) Environ Chem Lett. Online first, 25 (Nov) in press. doi:10.1007/s10311-010-0304-0

  25. Yellappa S, Seetharamappa Y, Rogers LM, Chitta R, Singhal RP, D`Souza F (2006) Bioconjugate Chem 17:1418

    Article  CAS  Google Scholar 

  26. Caemelbecke EV, Derbin A, Hambright P, Garcia R, Doukkali A, Saoiabi A, Ohkubo K, Fukuzumi S, Kadish KM (2005) Inorg Chem 44(11):3789

    Article  Google Scholar 

  27. Kadish KM, Caemelbecke EV (2003) J Solid State Chem 7(5):254

    CAS  Google Scholar 

  28. Yoshiki O, Hoshino A, Okamura T, Hidehiro U, Daisuke H, Akira I, Nakamura M (2007) Inorg Chem 46(20):8193

    Article  Google Scholar 

  29. Nakamura M (2006) Coord Chem Rev 250:2271

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors would like to acknowledge final support through a Grand-in-Aid C (No. 21550086) from The Ministry of Education, Science, Technology, Sports and Culture (MEXT), Japan and a Japan Science Promotion Society (JSPS) Post-Doctoral Fellowship for Foreign Researchers (PE-007).

Author information

Authors and Affiliations

  1. Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo-machi, Saga, 840-8502, Japan

    Nanda Gunawardhana, Shingo Homi & Masaaki Tabata

Authors
  1. Nanda Gunawardhana
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shingo Homi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masaaki Tabata
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Nanda Gunawardhana or Masaaki Tabata.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 791 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gunawardhana, N., Homi, S. & Tabata, M. Reductively Induced Catalytic DNA Cleavage of Water Soluble RhIII-Br8TMPyP. Catal Lett 141, 1803–1807 (2011). https://doi.org/10.1007/s10562-011-0718-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10562-011-0718-8

Keywords

Search

Navigation