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Facile and Efficient Reductive Homocoupling of Benzyl and Aryl Halides Catalyzed by Ionic Liquid [C12mim][CuCl2] in the Presence of Metallic Zinc and Copper

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Abstract

A facile and efficient synthesis of bibenzyl and biaryl derivatives by reductive homocoupling reaction is described. Treatment of benzyl and aryl halides with metallic zinc and copper powder in the presence of a catalytic amount of [C12mim][CuCl2] under ligand- and base-free conditions gives the corresponding bibenzyls and biaryls in good to high yields. The product can be isolated by a simple extraction with organic solvent, and the catalytic system can be recycled or reused without any significant loss of catalytic activity.

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Acknowledgments

We thank the National Basic Research Program (973) of China (No. 613740101) and Natural Science Foundation of Jiangsu Province for support of this research.

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Authors and Affiliations

  1. College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, People’s Republic of China

    Yu-Lin Hu, Guo-Liang Gu & Ming Lu

  2. College of Pharmacy, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China

    Fu Li

Authors
  1. Yu-Lin Hu
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  2. Fu Li
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  3. Guo-Liang Gu
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  4. Ming Lu
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Correspondence to Ming Lu.

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Hu, YL., Li, F., Gu, GL. et al. Facile and Efficient Reductive Homocoupling of Benzyl and Aryl Halides Catalyzed by Ionic Liquid [C12mim][CuCl2] in the Presence of Metallic Zinc and Copper. Catal Lett 141, 467–473 (2011). https://doi.org/10.1007/s10562-010-0535-5

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  • DOI: https://doi.org/10.1007/s10562-010-0535-5

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