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Selective N-Alkylation of Aromatic Primary Amines Catalyzed by Bio-catalyst or Deep Eutectic Solvent

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Abstract

Biocatalysts or deep eutectic solvents (DES) are effective for selective N-alkylation of various aromatic primary amines. These methods avoided complexity of multiple alkylations giving products in good yields. Both DES and lipase can be recycled and re-used at least five times. In addition, these catalysts are biodegradable, non-toxic and cost-effective.

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Acknowledgments

Authors are thankful to UGC-CAS for providing fellowship and Institute of Chemical Technology, SAIF IIT—Bombay and Institute of Science, Mumbai for recording 1H NMR, IR and Mass spectra.

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Authors and Affiliations

  1. Dyestuff Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, Maharashtra, 400019, India

    Balvant Singh, Hyacintha Lobo & Ganapati Shankarling

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  1. Balvant Singh
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  2. Hyacintha Lobo
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  3. Ganapati Shankarling
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Correspondence to Ganapati Shankarling.

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Singh, B., Lobo, H. & Shankarling, G. Selective N-Alkylation of Aromatic Primary Amines Catalyzed by Bio-catalyst or Deep Eutectic Solvent. Catal Lett 141, 178–182 (2011). https://doi.org/10.1007/s10562-010-0479-9

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  • DOI: https://doi.org/10.1007/s10562-010-0479-9

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