Potassium Phosphate Catalyzed a Rapid Three-Component Synthesis of Tetrahydrobenzo[b]pyran at Ambient Temperature

Catalysis Letters volume 132, pages104–108(2009)Cite this article

Abstract

An efficient, rapid, one-pot synthesis of tetrahydrobenzo[b]pyran is achieved via a three-component reaction of aldehydes, 1,3-diketone, malononitrile in 20% ethanol using anhydrous potassium phosphate as a catalyst at room temperature. The key advantages are the short reaction time, high yields, simple work-up, inexpensive catalyst and purification of products by non-chromatographic methods, i.e. by simple recrystallization from ethanol.

Graphical Abstract

An efficient, rapid, one-pot synthesis of tetrahydrobenzo[b]pyran is achieved via a three-component reaction of aldehydes, dimedone, malononitrile in 20% ethanol using anhydrous potassium phosphate as a catalyst at room temperature. The key advantages are the short reaction time, high yields, simple work-up, inexpensive catalyst and purification of products by non-chromatographic methods, i.e. by simple recrystallization from ethanol.

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Scheme 1
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Acknowledgments

Authors DMP and KAU thank UGC, New Delhi for financial assistance [F.2-3/2007(Policy/SR)] and for the Research Fellowship, respectively.

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Affiliations

  1. Department of Chemistry, Shivaji University, Kolhapur, 416004, India

    D. M. Pore, K. A. Undale, B. B. Dongare & U. V. Desai

Authors
  1. D. M. Pore
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  2. K. A. Undale
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  3. B. B. Dongare
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  4. U. V. Desai
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Correspondence to D. M. Pore.

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Pore, D.M., Undale, K.A., Dongare, B.B. et al. Potassium Phosphate Catalyzed a Rapid Three-Component Synthesis of Tetrahydrobenzo[b]pyran at Ambient Temperature. Catal Lett 132, 104–108 (2009). https://doi.org/10.1007/s10562-009-0074-0

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Keywords

  • Three-component
  • Tetrahydrobenzo[b]pyran
  • Potassium phosphate
  • One-pot synthesis