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Synthesis of Bis(indolyl)methanes Using Recyclable PEG-Supported Sulfonic Acid as Catalyst

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Abstract

An operationally simple, efficient and environmentally benign synthetic method to bis(indolyl)methanes has been developed in good yields (80–96%) by electrophilic substitution reactions of indole with aldehydes or ketones in methanol in the presence of 5 mol% of poly (ethylene-glycol) (PEG) supported sulfonic acid with respect to indole under mild conditions. Recovery and recycling of the poly (ethylene-glycol)-supported catalyst were also described.

Graphical Abstract

A simple, facile and environmentally benign synthesis of bis(indolyl)methanes in good yields by reaction of indole with aldehydes or ketones in methanol using recyclable PEG-supported sulfonic acid as catalyst is described.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 20562005), NSF of Jiangxi Province (No. 0620021 and No. 2007GZW0185) and the Educational Committee of Jiangxi Province (GJJ08165).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, 330022, Nanchang, People’s Republic of China

    Shou-Ri Sheng, Qiu-Ying Wang, Yan Ding, Xiao-Ling Liu & Ming-Zhong Cai

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  1. Shou-Ri Sheng
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  2. Qiu-Ying Wang
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  3. Yan Ding
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  4. Xiao-Ling Liu
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  5. Ming-Zhong Cai
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Correspondence to Shou-Ri Sheng.

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Sheng, SR., Wang, QY., Ding, Y. et al. Synthesis of Bis(indolyl)methanes Using Recyclable PEG-Supported Sulfonic Acid as Catalyst. Catal Lett 128, 418–422 (2009). https://doi.org/10.1007/s10562-008-9767-z

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  • DOI: https://doi.org/10.1007/s10562-008-9767-z

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